High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. While recent studies have shown HLA-E can present diverse peptides to NK cells and T cells, the HLA-E repertoire recognized by CD94/NKG2x has remained poorly defined, with only a limited number of peptid...

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Detalles Bibliográficos
Autores principales: Huisman, Brooke D., Guan, Ning, Rückert, Timo, Garner, Lee, Singh, Nishant K., McMichael, Andrew J., Gillespie, Geraldine M., Romagnani, Chiara, Birnbaum, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412585/
https://www.ncbi.nlm.nih.gov/pubmed/37558657
http://dx.doi.org/10.1038/s41467-023-40220-1

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