Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels

Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH kinase (BDK)-mediated phosphorylation. Screening efforts to...

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Detalles Bibliográficos
Autores principales: Roth Flach, Rachel J., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Kormos, Bethany L., Liu, Shenping, Reese, Matthew R., Martinez Alsina, Luis A., Buzon, Leanne, Zhang, Yuan, Bechle, Bruce, Rosado, Amy, Sahasrabudhe, Parag V., Knafels, John, Bhattacharya, Samit K., Omoto, Kiyoyuki, Stansfield, John C., Hurley, Liam D., Song, LouJin, Luo, Lina, Breitkopf, Susanne B., Monetti, Mara, Cunio, Teresa, Tierney, Brendan, Geoly, Frank J., Delmore, Jake, Siddall, C. Parker, Xue, Liang, Yip, Ka N., Kalgutkar, Amit S., Miller, Russell A., Zhang, Bei B., Filipski, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412597/
https://www.ncbi.nlm.nih.gov/pubmed/37558654
http://dx.doi.org/10.1038/s41467-023-40536-y

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