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Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos

Somatic cell nuclear transfer (SCNT) can be used to reprogram differentiated somatic cells to a totipotent state but has poor efficiency in supporting full-term development. H3K9me3 is considered to be an epigenetic barrier to zygotic genomic activation in 2-cell SCNT embryos. However, the mechanism...

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Detalles Bibliográficos
Autores principales:	Xu, Ruimin, Zhu, Qianshu, Zhao, Yuyan, Chen, Mo, Yang, Lingyue, Shen, Shijun, Yang, Guang, Shi, Zhifei, Zhang, Xiaolei, Shi, Qi, Kou, Xiaochen, Zhao, Yanhong, Wang, Hong, Jiang, Cizhong, Li, Chong, Gao, Shaorong, Liu, Xiaoyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412629/ https://www.ncbi.nlm.nih.gov/pubmed/37558707 http://dx.doi.org/10.1038/s41467-023-40496-3

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