Multivalent adaptor proteins specifically target NK cells carrying a universal chimeric antigen receptor to ErbB2 (HER2)-expressing cancers

Chimeric antigen receptor (CAR)-engineered immune effector cells constitute a promising approach for adoptive cancer immunotherapy. Nevertheless, on-target/off-tumor toxicity and immune escape due to antigen loss represent considerable challenges. These may be overcome by adaptor CARs that are selec...

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Detalles Bibliográficos
Autores principales: Pfeifer Serrahima, Jordi, Zhang, Congcong, Oberoi, Pranav, Bodden, Malena, Röder, Jasmin, Arndt, Claudia, Feldmann, Anja, Kiefer, Anne, Prüfer, Maren, Kühnel, Ines, Tonn, Torsten, Bachmann, Michael, Wels, Winfried S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412657/
https://www.ncbi.nlm.nih.gov/pubmed/36688995
http://dx.doi.org/10.1007/s00262-023-03374-x

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