DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development

Drak2-deficient (Drak2(−/−)) mice are resistant to multiple models of autoimmunity yet effectively eliminate pathogens and tumors. Thus, DRAK2 represents a potential target to treat autoimmune diseases. However, the mechanisms by which DRAK2 contributes to autoimmunity, particularly type 1 diabetes...

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Detalles Bibliográficos
Autores principales: Mandarano, Alexandra H., Harris, Tarsha L., Creasy, Blaine M., Wehenkel, Marie, Duggar, Marygrace, Wilander, Benjamin A., Mishra, Ashutosh, Crawford, Jeremy Chase, Mullen, Sarah A., Williams, Katherine M., Pillai, Meenu, High, Anthony A., McGargill, Maureen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412737/
https://www.ncbi.nlm.nih.gov/pubmed/36773294
http://dx.doi.org/10.1016/j.celrep.2023.112106

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