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Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis
Rhabdomyolysis is a known side effect of levetiracetam. In general, a patient with rhabdomyolysis complains of muscle pain and swelling. Herein, we report four cases of asymptomatic levetiracetam-induced rhabdomyolysis. In all the four cases, the seizures resolved after more than five days. The pati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412751/ https://www.ncbi.nlm.nih.gov/pubmed/37575737 http://dx.doi.org/10.7759/cureus.41666 |
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author | Saito, Satoshi Iijima, Mutsumi Ikeguchi, Ryotaro Ishizuka, Kentaro Kitagawa, Kazuo |
author_facet | Saito, Satoshi Iijima, Mutsumi Ikeguchi, Ryotaro Ishizuka, Kentaro Kitagawa, Kazuo |
author_sort | Saito, Satoshi |
collection | PubMed |
description | Rhabdomyolysis is a known side effect of levetiracetam. In general, a patient with rhabdomyolysis complains of muscle pain and swelling. Herein, we report four cases of asymptomatic levetiracetam-induced rhabdomyolysis. In all the four cases, the seizures resolved after more than five days. The patients received continuous fluid replacement from the time they were admitted to our hospital. However, serum creatine kinase (CK) levels continued to rise without symptoms consistent with rhabdomyolysis. The serum CK level improved rapidly when levetiracetam was replaced with lacosamide. Because levetiracetam occasionally causes asymptomatic rhabdomyolysis, routine blood tests should be performed after its initiation. |
format | Online Article Text |
id | pubmed-10412751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-104127512023-08-11 Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis Saito, Satoshi Iijima, Mutsumi Ikeguchi, Ryotaro Ishizuka, Kentaro Kitagawa, Kazuo Cureus Internal Medicine Rhabdomyolysis is a known side effect of levetiracetam. In general, a patient with rhabdomyolysis complains of muscle pain and swelling. Herein, we report four cases of asymptomatic levetiracetam-induced rhabdomyolysis. In all the four cases, the seizures resolved after more than five days. The patients received continuous fluid replacement from the time they were admitted to our hospital. However, serum creatine kinase (CK) levels continued to rise without symptoms consistent with rhabdomyolysis. The serum CK level improved rapidly when levetiracetam was replaced with lacosamide. Because levetiracetam occasionally causes asymptomatic rhabdomyolysis, routine blood tests should be performed after its initiation. Cureus 2023-07-10 /pmc/articles/PMC10412751/ /pubmed/37575737 http://dx.doi.org/10.7759/cureus.41666 Text en Copyright © 2023, Saito et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Saito, Satoshi Iijima, Mutsumi Ikeguchi, Ryotaro Ishizuka, Kentaro Kitagawa, Kazuo Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis |
title | Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis |
title_full | Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis |
title_fullStr | Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis |
title_full_unstemmed | Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis |
title_short | Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis |
title_sort | four cases of suspected levetiracetam-induced asymptomatic rhabdomyolysis |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412751/ https://www.ncbi.nlm.nih.gov/pubmed/37575737 http://dx.doi.org/10.7759/cureus.41666 |
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