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Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models

Mutations in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The pathogenetic mechanisms linked to this gene are a direct consequence of an aberrant intronic expansion of a GGGGCC hexanucleotide located between the 1a and...

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Detalles Bibliográficos
Autores principales:	Seidel, Mira, Rajkumar, Sandeep, Steffke, Christina, Noeth, Vivien, Agarwal, Shreya, Roger, Kevin, Lipecka, Joanna, Ludolph, Albert, Guerrera, Chiara Ida, Boeckers, Tobias, Catanese, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412779/ https://www.ncbi.nlm.nih.gov/pubmed/37576491 http://dx.doi.org/10.1016/j.crneur.2023.100105

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