Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer

Ferroptosis, a genetically and biochemically distinct form of programmed cell death, is characterised by an iron-dependent accumulation of lipid peroxides. Therapy-resistant tumor cells display vulnerability toward ferroptosis. Endoplasmic Reticulum (ER) stress and Unfolded Protein Response (UPR) pl...

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Detalles Bibliográficos
Autores principales: Saini, Krishan Kumar, Chaturvedi, Priyank, Sinha, Abhipsa, Singh, Manish Pratap, Khan, Muqtada Ali, Verma, Ayushi, Nengroo, Mushtaq Ahmad, Satrusal, Saumya Ranjan, Meena, Sanjeev, Singh, Akhilesh, Srivastava, Sameer, Sarkar, Jayanta, Datta, Dipak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412847/
https://www.ncbi.nlm.nih.gov/pubmed/37536085
http://dx.doi.org/10.1016/j.redox.2023.102833

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