Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma

Various molecular subclasses of hepatocellular carcinoma (HCC) exists, with many novel cooperating oncogenes and tumor suppressor genes involved in its tumorigenesis. The emerging importance of WNT signaling in HCC has been established. However, the intricate genetic mechanisms involved in this comp...

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Detalles Bibliográficos
Autores principales: Keng, Vincent W., Chiu, Amy P., To, Jeffrey C., Li, Xiao-Xiao, Linden, Michael A., Amin, Khalid, Moriarity, Branden S., Yusa, Kosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412851/
https://www.ncbi.nlm.nih.gov/pubmed/37576222
http://dx.doi.org/10.1016/j.heliyon.2023.e18774

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