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Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review

Infantile fibrosarcoma (IFS) is a rare tumor in childhood characterized by a single, localized, painless mass that grows rapidly but has a relatively indolent biological behavior and a favorable prognosis. Eighty-five percent of infantile fibrosarcomas are associated with t (12;15) (p13;25) chromoso...

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Autores principales: Wang, Dandan, Zhang, Fanhui, Feng, Wanli, Pan, Jiarong, Yuan, Tianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412926/
https://www.ncbi.nlm.nih.gov/pubmed/37576877
http://dx.doi.org/10.3389/fonc.2023.1206833
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author Wang, Dandan
Zhang, Fanhui
Feng, Wanli
Pan, Jiarong
Yuan, Tianming
author_facet Wang, Dandan
Zhang, Fanhui
Feng, Wanli
Pan, Jiarong
Yuan, Tianming
author_sort Wang, Dandan
collection PubMed
description Infantile fibrosarcoma (IFS) is a rare tumor in childhood characterized by a single, localized, painless mass that grows rapidly but has a relatively indolent biological behavior and a favorable prognosis. Eighty-five percent of infantile fibrosarcomas are associated with t (12;15) (p13;25) chromosomal translocation resulting in ETV6-NTRK3 gene fusion, which provides the target for targeted therapy. Here, we report a case of IFS in a newborn with a mass in the left lower extremity confirmed by imaging, histopathological examination, tissue FISH testing, and high-throughput sequencing to detect gene rearrangement. Based on gene fusion targeted drug testing results, the patient was treated with standard doses of larotrectinib, resulting in significant mass shrinkage with no adverse effects, demonstrating the treatment effect of targeted therapy. This case provides a reference for using larotrectinib in newborns with IFS.
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spelling pubmed-104129262023-08-11 Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review Wang, Dandan Zhang, Fanhui Feng, Wanli Pan, Jiarong Yuan, Tianming Front Oncol Oncology Infantile fibrosarcoma (IFS) is a rare tumor in childhood characterized by a single, localized, painless mass that grows rapidly but has a relatively indolent biological behavior and a favorable prognosis. Eighty-five percent of infantile fibrosarcomas are associated with t (12;15) (p13;25) chromosomal translocation resulting in ETV6-NTRK3 gene fusion, which provides the target for targeted therapy. Here, we report a case of IFS in a newborn with a mass in the left lower extremity confirmed by imaging, histopathological examination, tissue FISH testing, and high-throughput sequencing to detect gene rearrangement. Based on gene fusion targeted drug testing results, the patient was treated with standard doses of larotrectinib, resulting in significant mass shrinkage with no adverse effects, demonstrating the treatment effect of targeted therapy. This case provides a reference for using larotrectinib in newborns with IFS. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10412926/ /pubmed/37576877 http://dx.doi.org/10.3389/fonc.2023.1206833 Text en Copyright © 2023 Wang, Zhang, Feng, Pan and Yuan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Dandan
Zhang, Fanhui
Feng, Wanli
Pan, Jiarong
Yuan, Tianming
Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review
title Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review
title_full Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review
title_fullStr Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review
title_full_unstemmed Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review
title_short Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review
title_sort larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412926/
https://www.ncbi.nlm.nih.gov/pubmed/37576877
http://dx.doi.org/10.3389/fonc.2023.1206833
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