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The dendritic engram
Accumulating evidence from a wide range of studies, including behavioral, cellular, molecular and computational findings, support a key role of dendrites in the encoding and recall of new memories. Dendrites can integrate synaptic inputs in non-linear ways, provide the substrate for local protein sy...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412934/ https://www.ncbi.nlm.nih.gov/pubmed/37576932 http://dx.doi.org/10.3389/fnbeh.2023.1212139 |
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author | Kastellakis, George Tasciotti, Simone Pandi, Ioanna Poirazi, Panayiota |
author_facet | Kastellakis, George Tasciotti, Simone Pandi, Ioanna Poirazi, Panayiota |
author_sort | Kastellakis, George |
collection | PubMed |
description | Accumulating evidence from a wide range of studies, including behavioral, cellular, molecular and computational findings, support a key role of dendrites in the encoding and recall of new memories. Dendrites can integrate synaptic inputs in non-linear ways, provide the substrate for local protein synthesis and facilitate the orchestration of signaling pathways that regulate local synaptic plasticity. These capabilities allow them to act as a second layer of computation within the neuron and serve as the fundamental unit of plasticity. As such, dendrites are integral parts of the memory engram, namely the physical representation of memories in the brain and are increasingly studied during learning tasks. Here, we review experimental and computational studies that support a novel, dendritic view of the memory engram that is centered on non-linear dendritic branches as elementary memory units. We highlight the potential implications of dendritic engrams for the learning and memory field and discuss future research directions. |
format | Online Article Text |
id | pubmed-10412934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104129342023-08-11 The dendritic engram Kastellakis, George Tasciotti, Simone Pandi, Ioanna Poirazi, Panayiota Front Behav Neurosci Neuroscience Accumulating evidence from a wide range of studies, including behavioral, cellular, molecular and computational findings, support a key role of dendrites in the encoding and recall of new memories. Dendrites can integrate synaptic inputs in non-linear ways, provide the substrate for local protein synthesis and facilitate the orchestration of signaling pathways that regulate local synaptic plasticity. These capabilities allow them to act as a second layer of computation within the neuron and serve as the fundamental unit of plasticity. As such, dendrites are integral parts of the memory engram, namely the physical representation of memories in the brain and are increasingly studied during learning tasks. Here, we review experimental and computational studies that support a novel, dendritic view of the memory engram that is centered on non-linear dendritic branches as elementary memory units. We highlight the potential implications of dendritic engrams for the learning and memory field and discuss future research directions. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10412934/ /pubmed/37576932 http://dx.doi.org/10.3389/fnbeh.2023.1212139 Text en Copyright © 2023 Kastellakis, Tasciotti, Pandi and Poirazi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Kastellakis, George Tasciotti, Simone Pandi, Ioanna Poirazi, Panayiota The dendritic engram |
title | The dendritic engram |
title_full | The dendritic engram |
title_fullStr | The dendritic engram |
title_full_unstemmed | The dendritic engram |
title_short | The dendritic engram |
title_sort | dendritic engram |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412934/ https://www.ncbi.nlm.nih.gov/pubmed/37576932 http://dx.doi.org/10.3389/fnbeh.2023.1212139 |
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