Putative malignant hyperthermia mutation Ca(V)1.1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance

Malignant hyperthermia susceptibility (MHS) is an autosomal dominant pharmacogenetic disorder that manifests as a hypermetabolic state when carriers are exposed to halogenated volatile anesthetics or depolarizing muscle relaxants. In animals, heat stress intolerance is also observed. MHS is linked t...

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Detalles Bibliográficos
Autores principales: Feng, Wei, Lopez, Jose R., Antrobus, Shane, Zheng, Jing, Uryash, Arkady, Dong, Yao, Beqollari, Donald, Bannister, Roger A., Hopkins, Philip M., Beam, Kurt G., Allen, Paul D., Pessah, Isaac.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413282/
https://www.ncbi.nlm.nih.gov/pubmed/37392848
http://dx.doi.org/10.1016/j.jbc.2023.104992

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