Label-Free Raman Spectromicroscopy Unravels the Relationship between MGMT Methylation and Intracellular Lipid Accumulation in Glioblastoma

[Image: see text] Temozolomide (TMZ) is considered a first line chemotherapy drug for glioblastoma (GBM). Unfortunately, the GBM without methylation of O(6)-methylguanine-DNA methyltransferase (MGMT), accounting for about 70% of all GBM, shows an inherent resistance to TMZ treatment. Aberrant accumu...

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Detalles Bibliográficos
Autores principales: Wang, Nana, Wang, Jiejun, Wang, Pu, Ji, Nan, Yue, Shuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413324/
https://www.ncbi.nlm.nih.gov/pubmed/37417930
http://dx.doi.org/10.1021/acs.analchem.3c00967

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