Neurological Sequelae of COVID-19: A Biochemical Perspective

[Image: see text] Exogenous factors can induce protein expression and modify the proteome which sustains for a certain period of time. The proteins of SARS-CoV-2 are high in valine plus glycine, which possess potent affinity to divalent cations such as calcium. Calcium buildup changes the protein ex...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoxiao, Zhang, Ying, Wen, Ling, Ouyang, Jess Lan, Zhang, Weiwei, Zhang, Jiaming, Wang, Yuchuan, Liu, Qiuyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413374/
https://www.ncbi.nlm.nih.gov/pubmed/37576681
http://dx.doi.org/10.1021/acsomega.3c04100
Descripción
Sumario:[Image: see text] Exogenous factors can induce protein expression and modify the proteome which sustains for a certain period of time. The proteins of SARS-CoV-2 are high in valine plus glycine, which possess potent affinity to divalent cations such as calcium. Calcium buildup changes the protein expression profile by enabling the efficient synthesis of proteins rich in amino acids with calcium affinity. Subsequent formation of insoluble and stiff calcium oxalate and aggregates confers cellular stress and causes cell senescence. This scenario accounts for sequelae seen in some patients following recovery from COVID-19.

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