Neurological Sequelae of COVID-19: A Biochemical Perspective

[Image: see text] Exogenous factors can induce protein expression and modify the proteome which sustains for a certain period of time. The proteins of SARS-CoV-2 are high in valine plus glycine, which possess potent affinity to divalent cations such as calcium. Calcium buildup changes the protein ex...

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Autores principales: Zhang, Xiaoxiao, Zhang, Ying, Wen, Ling, Ouyang, Jess Lan, Zhang, Weiwei, Zhang, Jiaming, Wang, Yuchuan, Liu, Qiuyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413374/
https://www.ncbi.nlm.nih.gov/pubmed/37576681
http://dx.doi.org/10.1021/acsomega.3c04100
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author Zhang, Xiaoxiao
Zhang, Ying
Wen, Ling
Ouyang, Jess Lan
Zhang, Weiwei
Zhang, Jiaming
Wang, Yuchuan
Liu, Qiuyun
author_facet Zhang, Xiaoxiao
Zhang, Ying
Wen, Ling
Ouyang, Jess Lan
Zhang, Weiwei
Zhang, Jiaming
Wang, Yuchuan
Liu, Qiuyun
author_sort Zhang, Xiaoxiao
collection PubMed
description [Image: see text] Exogenous factors can induce protein expression and modify the proteome which sustains for a certain period of time. The proteins of SARS-CoV-2 are high in valine plus glycine, which possess potent affinity to divalent cations such as calcium. Calcium buildup changes the protein expression profile by enabling the efficient synthesis of proteins rich in amino acids with calcium affinity. Subsequent formation of insoluble and stiff calcium oxalate and aggregates confers cellular stress and causes cell senescence. This scenario accounts for sequelae seen in some patients following recovery from COVID-19.
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spelling pubmed-104133742023-08-11 Neurological Sequelae of COVID-19: A Biochemical Perspective Zhang, Xiaoxiao Zhang, Ying Wen, Ling Ouyang, Jess Lan Zhang, Weiwei Zhang, Jiaming Wang, Yuchuan Liu, Qiuyun ACS Omega [Image: see text] Exogenous factors can induce protein expression and modify the proteome which sustains for a certain period of time. The proteins of SARS-CoV-2 are high in valine plus glycine, which possess potent affinity to divalent cations such as calcium. Calcium buildup changes the protein expression profile by enabling the efficient synthesis of proteins rich in amino acids with calcium affinity. Subsequent formation of insoluble and stiff calcium oxalate and aggregates confers cellular stress and causes cell senescence. This scenario accounts for sequelae seen in some patients following recovery from COVID-19. American Chemical Society 2023-07-25 /pmc/articles/PMC10413374/ /pubmed/37576681 http://dx.doi.org/10.1021/acsomega.3c04100 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Zhang, Xiaoxiao
Zhang, Ying
Wen, Ling
Ouyang, Jess Lan
Zhang, Weiwei
Zhang, Jiaming
Wang, Yuchuan
Liu, Qiuyun
Neurological Sequelae of COVID-19: A Biochemical Perspective
title Neurological Sequelae of COVID-19: A Biochemical Perspective
title_full Neurological Sequelae of COVID-19: A Biochemical Perspective
title_fullStr Neurological Sequelae of COVID-19: A Biochemical Perspective
title_full_unstemmed Neurological Sequelae of COVID-19: A Biochemical Perspective
title_short Neurological Sequelae of COVID-19: A Biochemical Perspective
title_sort neurological sequelae of covid-19: a biochemical perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413374/
https://www.ncbi.nlm.nih.gov/pubmed/37576681
http://dx.doi.org/10.1021/acsomega.3c04100
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