Cargando…

Tetrandrine Derivatives as Promising Antibacterial Agents

[Image: see text] This work reports on the antibacterial activity of two tetrandrine derivatives, with acridine (MAcT) and anthracene (MAnT) units, against Gram-positive and Gram-negative bacteria of clinical importance by the broth microdilution method as well as their antioxidant activity against...

Descripción completa

Detalles Bibliográficos
Autores principales: Calvillo-Páez, Viviana I., Plascencia-Jatomea, Maribel, Ochoa-Terán, Adrián, Del-Toro-Sánchez, Carmen L., González-Vega, Ricardo I., González-Martínez, Sandra M., Ochoa Lara, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413380/
https://www.ncbi.nlm.nih.gov/pubmed/37576675
http://dx.doi.org/10.1021/acsomega.3c01368
_version_ 1785087116938575872
author Calvillo-Páez, Viviana I.
Plascencia-Jatomea, Maribel
Ochoa-Terán, Adrián
Del-Toro-Sánchez, Carmen L.
González-Vega, Ricardo I.
González-Martínez, Sandra M.
Ochoa Lara, Karen
author_facet Calvillo-Páez, Viviana I.
Plascencia-Jatomea, Maribel
Ochoa-Terán, Adrián
Del-Toro-Sánchez, Carmen L.
González-Vega, Ricardo I.
González-Martínez, Sandra M.
Ochoa Lara, Karen
author_sort Calvillo-Páez, Viviana I.
collection PubMed
description [Image: see text] This work reports on the antibacterial activity of two tetrandrine derivatives, with acridine (MAcT) and anthracene (MAnT) units, against Gram-positive and Gram-negative bacteria of clinical importance by the broth microdilution method as well as their antioxidant activity against ABTS(•+) and DPPH(•+) radicals. Unlike natural tetrandrine, its derivatives inhibited bacterial growth, showing selectivity against Staphylococcus aureus with notable activity of MAnT (MIC = 0.035 μg/mL); this compound also has good activity against the ABTS(•+) radical (IC(50) = 4.59 μg/mL). Cell membrane integrity studies and reactive oxygen species (ROS) detection by fluorescent stains helped to understand possible mechanisms related to antibacterial activity, while electrophoretic mobility assays showed that the derivatives can bind to bacterial DNA plasmid. The results indicate that MAnT can induce a general state of oxidative stress in S. aureus and Escherichia coli, while MAcT induces an oxidative response in S. aureus. Complementary electrochemical studies were included.
format Online
Article
Text
id pubmed-10413380
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-104133802023-08-11 Tetrandrine Derivatives as Promising Antibacterial Agents Calvillo-Páez, Viviana I. Plascencia-Jatomea, Maribel Ochoa-Terán, Adrián Del-Toro-Sánchez, Carmen L. González-Vega, Ricardo I. González-Martínez, Sandra M. Ochoa Lara, Karen ACS Omega [Image: see text] This work reports on the antibacterial activity of two tetrandrine derivatives, with acridine (MAcT) and anthracene (MAnT) units, against Gram-positive and Gram-negative bacteria of clinical importance by the broth microdilution method as well as their antioxidant activity against ABTS(•+) and DPPH(•+) radicals. Unlike natural tetrandrine, its derivatives inhibited bacterial growth, showing selectivity against Staphylococcus aureus with notable activity of MAnT (MIC = 0.035 μg/mL); this compound also has good activity against the ABTS(•+) radical (IC(50) = 4.59 μg/mL). Cell membrane integrity studies and reactive oxygen species (ROS) detection by fluorescent stains helped to understand possible mechanisms related to antibacterial activity, while electrophoretic mobility assays showed that the derivatives can bind to bacterial DNA plasmid. The results indicate that MAnT can induce a general state of oxidative stress in S. aureus and Escherichia coli, while MAcT induces an oxidative response in S. aureus. Complementary electrochemical studies were included. American Chemical Society 2023-07-26 /pmc/articles/PMC10413380/ /pubmed/37576675 http://dx.doi.org/10.1021/acsomega.3c01368 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Calvillo-Páez, Viviana I.
Plascencia-Jatomea, Maribel
Ochoa-Terán, Adrián
Del-Toro-Sánchez, Carmen L.
González-Vega, Ricardo I.
González-Martínez, Sandra M.
Ochoa Lara, Karen
Tetrandrine Derivatives as Promising Antibacterial Agents
title Tetrandrine Derivatives as Promising Antibacterial Agents
title_full Tetrandrine Derivatives as Promising Antibacterial Agents
title_fullStr Tetrandrine Derivatives as Promising Antibacterial Agents
title_full_unstemmed Tetrandrine Derivatives as Promising Antibacterial Agents
title_short Tetrandrine Derivatives as Promising Antibacterial Agents
title_sort tetrandrine derivatives as promising antibacterial agents
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413380/
https://www.ncbi.nlm.nih.gov/pubmed/37576675
http://dx.doi.org/10.1021/acsomega.3c01368
work_keys_str_mv AT calvillopaezvivianai tetrandrinederivativesaspromisingantibacterialagents
AT plascenciajatomeamaribel tetrandrinederivativesaspromisingantibacterialagents
AT ochoateranadrian tetrandrinederivativesaspromisingantibacterialagents
AT deltorosanchezcarmenl tetrandrinederivativesaspromisingantibacterialagents
AT gonzalezvegaricardoi tetrandrinederivativesaspromisingantibacterialagents
AT gonzalezmartinezsandram tetrandrinederivativesaspromisingantibacterialagents
AT ochoalarakaren tetrandrinederivativesaspromisingantibacterialagents