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Identification of the Brucea javanica Constituent Brusatol as a EGFR-Tyrosine Kinase Inhibitor in a Cell-Free Assay

[Image: see text] Inhibitors of the tyrosine kinase (TK) activity of the epidermal growth factor receptor (EGFR) are routinely used in cancer therapy. However, there is a need to discover a new TK inhibitor. This study evaluated extracts from Brucea javanica and its components for their potential as...

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Detalles Bibliográficos
Autores principales:	Suwattanasophon, Chonticha, Mistlberger-Reiner, Agnes, Alberdi-Cedeño, Jon, Pignitter, Marc, Somoza, Veronika, König, Jürgen, Lamtha, Thomanai, Wanaragthai, Panatda, Kiriwan, Duangnapa, Choowongkomon, Kiattawee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413460/ https://www.ncbi.nlm.nih.gov/pubmed/37576644 http://dx.doi.org/10.1021/acsomega.3c02931

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