CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor and has “immunologically cold” features. Changing GBM to an “immunologically hot” tumor requires a strong trigger that induces initial immune responses in GBM. Allogeneic natural killer cells (NKCs) have gained considerable atte...

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Detalles Bibliográficos
Autores principales: Nakazawa, Tsutomu, Morimoto, Takayuki, Maeoka, Ryosuke, Matsuda, Ryosuke, Nakamura, Mitsutoshi, Nishimura, Fumihiko, Ouji, Noriko, Yamada, Shuichi, Nakagawa, Ichiro, Park, Young Soo, Ito, Toshihiro, Nakase, Hiroyuki, Tsujimura, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413513/
https://www.ncbi.nlm.nih.gov/pubmed/37563692
http://dx.doi.org/10.1186/s13046-023-02770-6

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