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TMEM106B aggregation in neurodegenerative diseases: linking genetics to function
BACKGROUND: Mutations of the gene TMEM106B are risk factors for diverse neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413548/ https://www.ncbi.nlm.nih.gov/pubmed/37563705 http://dx.doi.org/10.1186/s13024-023-00644-1 |