Cargando…

Increased posterior cingulate cortex blood flow in cancer-related fatigue

Fatigue is a common symptom associated with cancer treatments. Brain mechanisms underlying cancer-related fatigue (CRF) and its progression following therapy are poorly understood. Previous studies have suggested a role of the default mode network (DMN) in fatigue. In this study we used arterial spi...

Descripción completa

Detalles Bibliográficos
Autores principales: Raizen, David, Bhavsar, Rupal, Keenan, Brendan T., Liu, Patrick Z., Kegelman, Timothy P., Chao, Hann-Hsiang, Vapiwala, Neha, Rao, Hengyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413554/
https://www.ncbi.nlm.nih.gov/pubmed/37576014
http://dx.doi.org/10.3389/fneur.2023.1135462
_version_ 1785087153969037312
author Raizen, David
Bhavsar, Rupal
Keenan, Brendan T.
Liu, Patrick Z.
Kegelman, Timothy P.
Chao, Hann-Hsiang
Vapiwala, Neha
Rao, Hengyi
author_facet Raizen, David
Bhavsar, Rupal
Keenan, Brendan T.
Liu, Patrick Z.
Kegelman, Timothy P.
Chao, Hann-Hsiang
Vapiwala, Neha
Rao, Hengyi
author_sort Raizen, David
collection PubMed
description Fatigue is a common symptom associated with cancer treatments. Brain mechanisms underlying cancer-related fatigue (CRF) and its progression following therapy are poorly understood. Previous studies have suggested a role of the default mode network (DMN) in fatigue. In this study we used arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) and compared resting cerebral blood flow (CBF) differences in the posterior cingulate cortex (PCC), a core hub of the DMN, between 16 patients treated with radiation therapy (RAT) for prostate (9 males) or breast (7 females) cancer and 18 healthy controls (HC). Resting CBF in patients was also measured immediately after the performance of a fatiguing 20-min psychomotor vigilance task (PVT). Twelve of 16 cancer patients were further followed between 3 and 7 months after completion of the RAT (post-RAT). Patients reported elevated fatigue on RAT in comparison to post-RAT, but no change in sleepiness, suggesting that the underlying neural mechanisms of CRF progression are distinct from those regulating sleep drive progression. Compared to HC, patients showed significantly increased resting CBF in the PCC and the elevated PCC CBF persisted during the follow up visit. Post-PVT, but not pre-PVT, resting CBF changes in the PCC correlated with fatigue changes after therapy in patients with CRF, suggesting that PCC CBF following a fatiguing cognitive task may be a biomarker for CRF recovery.
format Online
Article
Text
id pubmed-10413554
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104135542023-08-11 Increased posterior cingulate cortex blood flow in cancer-related fatigue Raizen, David Bhavsar, Rupal Keenan, Brendan T. Liu, Patrick Z. Kegelman, Timothy P. Chao, Hann-Hsiang Vapiwala, Neha Rao, Hengyi Front Neurol Neurology Fatigue is a common symptom associated with cancer treatments. Brain mechanisms underlying cancer-related fatigue (CRF) and its progression following therapy are poorly understood. Previous studies have suggested a role of the default mode network (DMN) in fatigue. In this study we used arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) and compared resting cerebral blood flow (CBF) differences in the posterior cingulate cortex (PCC), a core hub of the DMN, between 16 patients treated with radiation therapy (RAT) for prostate (9 males) or breast (7 females) cancer and 18 healthy controls (HC). Resting CBF in patients was also measured immediately after the performance of a fatiguing 20-min psychomotor vigilance task (PVT). Twelve of 16 cancer patients were further followed between 3 and 7 months after completion of the RAT (post-RAT). Patients reported elevated fatigue on RAT in comparison to post-RAT, but no change in sleepiness, suggesting that the underlying neural mechanisms of CRF progression are distinct from those regulating sleep drive progression. Compared to HC, patients showed significantly increased resting CBF in the PCC and the elevated PCC CBF persisted during the follow up visit. Post-PVT, but not pre-PVT, resting CBF changes in the PCC correlated with fatigue changes after therapy in patients with CRF, suggesting that PCC CBF following a fatiguing cognitive task may be a biomarker for CRF recovery. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10413554/ /pubmed/37576014 http://dx.doi.org/10.3389/fneur.2023.1135462 Text en Copyright © 2023 Raizen, Bhavsar, Keenan, Liu, Kegelman, Chao, Vapiwala and Rao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Raizen, David
Bhavsar, Rupal
Keenan, Brendan T.
Liu, Patrick Z.
Kegelman, Timothy P.
Chao, Hann-Hsiang
Vapiwala, Neha
Rao, Hengyi
Increased posterior cingulate cortex blood flow in cancer-related fatigue
title Increased posterior cingulate cortex blood flow in cancer-related fatigue
title_full Increased posterior cingulate cortex blood flow in cancer-related fatigue
title_fullStr Increased posterior cingulate cortex blood flow in cancer-related fatigue
title_full_unstemmed Increased posterior cingulate cortex blood flow in cancer-related fatigue
title_short Increased posterior cingulate cortex blood flow in cancer-related fatigue
title_sort increased posterior cingulate cortex blood flow in cancer-related fatigue
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413554/
https://www.ncbi.nlm.nih.gov/pubmed/37576014
http://dx.doi.org/10.3389/fneur.2023.1135462
work_keys_str_mv AT raizendavid increasedposteriorcingulatecortexbloodflowincancerrelatedfatigue
AT bhavsarrupal increasedposteriorcingulatecortexbloodflowincancerrelatedfatigue
AT keenanbrendant increasedposteriorcingulatecortexbloodflowincancerrelatedfatigue
AT liupatrickz increasedposteriorcingulatecortexbloodflowincancerrelatedfatigue
AT kegelmantimothyp increasedposteriorcingulatecortexbloodflowincancerrelatedfatigue
AT chaohannhsiang increasedposteriorcingulatecortexbloodflowincancerrelatedfatigue
AT vapiwalaneha increasedposteriorcingulatecortexbloodflowincancerrelatedfatigue
AT raohengyi increasedposteriorcingulatecortexbloodflowincancerrelatedfatigue