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The role of gut microbiome in the complex relationship between respiratory tract infection and asthma

Asthma is one of the common chronic respiratory diseases in children, which poses a serious threat to children's quality of life. Respiratory infection is a risk factor for asthma. Compared with healthy children, children with early respiratory infections have a higher risk of asthma and an inc...

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Autores principales: Zhao, Xiaoman, Hu, Mingge, Zhou, Huan, Yang, Yan, Shen, Shiping, You, Yannan, Xue, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413575/
https://www.ncbi.nlm.nih.gov/pubmed/37577440
http://dx.doi.org/10.3389/fmicb.2023.1219942
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author Zhao, Xiaoman
Hu, Mingge
Zhou, Huan
Yang, Yan
Shen, Shiping
You, Yannan
Xue, Zheng
author_facet Zhao, Xiaoman
Hu, Mingge
Zhou, Huan
Yang, Yan
Shen, Shiping
You, Yannan
Xue, Zheng
author_sort Zhao, Xiaoman
collection PubMed
description Asthma is one of the common chronic respiratory diseases in children, which poses a serious threat to children's quality of life. Respiratory infection is a risk factor for asthma. Compared with healthy children, children with early respiratory infections have a higher risk of asthma and an increased chance of developing severe asthma. Many clinical studies have confirmed the correlation between respiratory infections and the pathogenesis of asthma, but the underlying mechanism is still unclear. The gut microbiome is an important part of maintaining the body's immune homeostasis. The imbalance of the gut microbiome can affect the lung immune function, and then affect lung health and cause respiratory diseases. A large number of evidence supports that there is a bidirectional regulation between intestinal flora and respiratory tract infection, and both are significantly related to the development of asthma. The changes of intestinal microbial components and their metabolites in respiratory tract infection may affect the occurrence and development of asthma through the immune pathway. By summarizing the latest advancements in research, this review aims to elucidate the intricate connection between respiratory tract infections and the progression of asthma by highlighting its bridging role of the gut microbiome. Furthermore, it offers novel perspectives and ideas for future investigations into the mechanisms that underlie the relationship between respiratory tract infections and asthma.
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spelling pubmed-104135752023-08-11 The role of gut microbiome in the complex relationship between respiratory tract infection and asthma Zhao, Xiaoman Hu, Mingge Zhou, Huan Yang, Yan Shen, Shiping You, Yannan Xue, Zheng Front Microbiol Microbiology Asthma is one of the common chronic respiratory diseases in children, which poses a serious threat to children's quality of life. Respiratory infection is a risk factor for asthma. Compared with healthy children, children with early respiratory infections have a higher risk of asthma and an increased chance of developing severe asthma. Many clinical studies have confirmed the correlation between respiratory infections and the pathogenesis of asthma, but the underlying mechanism is still unclear. The gut microbiome is an important part of maintaining the body's immune homeostasis. The imbalance of the gut microbiome can affect the lung immune function, and then affect lung health and cause respiratory diseases. A large number of evidence supports that there is a bidirectional regulation between intestinal flora and respiratory tract infection, and both are significantly related to the development of asthma. The changes of intestinal microbial components and their metabolites in respiratory tract infection may affect the occurrence and development of asthma through the immune pathway. By summarizing the latest advancements in research, this review aims to elucidate the intricate connection between respiratory tract infections and the progression of asthma by highlighting its bridging role of the gut microbiome. Furthermore, it offers novel perspectives and ideas for future investigations into the mechanisms that underlie the relationship between respiratory tract infections and asthma. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10413575/ /pubmed/37577440 http://dx.doi.org/10.3389/fmicb.2023.1219942 Text en Copyright © 2023 Zhao, Hu, Zhou, Yang, Shen, You and Xue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhao, Xiaoman
Hu, Mingge
Zhou, Huan
Yang, Yan
Shen, Shiping
You, Yannan
Xue, Zheng
The role of gut microbiome in the complex relationship between respiratory tract infection and asthma
title The role of gut microbiome in the complex relationship between respiratory tract infection and asthma
title_full The role of gut microbiome in the complex relationship between respiratory tract infection and asthma
title_fullStr The role of gut microbiome in the complex relationship between respiratory tract infection and asthma
title_full_unstemmed The role of gut microbiome in the complex relationship between respiratory tract infection and asthma
title_short The role of gut microbiome in the complex relationship between respiratory tract infection and asthma
title_sort role of gut microbiome in the complex relationship between respiratory tract infection and asthma
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413575/
https://www.ncbi.nlm.nih.gov/pubmed/37577440
http://dx.doi.org/10.3389/fmicb.2023.1219942
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