Concerted conformational changes control metabotropic glutamate receptor activity

Allosteric modulators bear great potential to fine-tune neurotransmitter action. Promising targets are metabotropic glutamate (mGlu) receptors, which are associated with numerous brain diseases. Orthosteric and allosteric ligands act in synergy to control the activity of these multidomain dimeric GP...

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Detalles Bibliográficos
Autores principales: Lecat-Guillet, Nathalie, Quast, Robert B., Liu, Hongkang, Bourrier, Emmanuel, Møller, Thor C., Rovira, Xavier, Soldevila, Stéphanie, Lamarque, Laurent, Trinquet, Eric, Liu, Jianfeng, Pin, Jean-Philippe, Rondard, Philippe, Margeat, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413646/
https://www.ncbi.nlm.nih.gov/pubmed/37267369
http://dx.doi.org/10.1126/sciadv.adf1378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413646/
https://www.ncbi.nlm.nih.gov/pubmed/37267369
http://dx.doi.org/10.1126/sciadv.adf1378

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