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PAXX binding to the NHEJ machinery explains functional redundancy with XLF

Nonhomologous end joining is a critical mechanism that repairs DNA double-strand breaks in human cells. In this work, we address the structural and functional role of the accessory protein PAXX [paralog of x-ray repair cross-complementing protein 4 (XRCC4) and XRCC4-like factor (XLF)] in this mechan...

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Detalles Bibliográficos
Autores principales:	Seif-El-Dahan, Murielle, Kefala-Stavridi, Antonia, Frit, Philippe, Hardwick, Steven W., Chirgadze, Dima Y., Maia De Oliviera, Taiana, Britton, Sébastien, Barboule, Nadia, Bossaert, Madeleine, Pandurangan, Arun Prasad, Meek, Katheryn, Blundell, Tom L., Ropars, Virginie, Calsou, Patrick, Charbonnier, Jean-Baptiste, Chaplin, Amanda K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413649/ https://www.ncbi.nlm.nih.gov/pubmed/37256950 http://dx.doi.org/10.1126/sciadv.adg2834

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