Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis

Hemodynamic overload and dysregulation of cellular metabolism are involved in development of calcific aortic valve disease (CAVD). However, how mechanical stress relates to metabolic changes in CAVD remains unclear. Here, we show that Piezo1, a mechanosensitive ion channel, regulated glutaminase 1 (...

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Detalles Bibliográficos
Autores principales: Zhong, Guoheng, Su, Shuwen, Li, Juncong, Zhao, Hengli, Hu, Dongtu, Chen, Jun, Li, Shichao, Lin, Yingwen, Wen, Liming, Lin, Xiangjie, Xian, Gaopeng, Xu, Dingli, Zeng, Qingchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413650/
https://www.ncbi.nlm.nih.gov/pubmed/37267365
http://dx.doi.org/10.1126/sciadv.adg0478

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