ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation

Autophagy and glycolysis are highly conserved biological processes involved in both physiological and pathological cellular programs, but the interplay between these processes is poorly understood. Here, we show that the glycolytic enzyme lactate dehydrogenase A (LDHA) is activated upon UNC-51–like...

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Detalles Bibliográficos
Autores principales: Jia, Mengshu, Yue, Xiao, Sun, Weixia, Zhou, Qianjun, Chang, Cheng, Gong, Weihua, Feng, Jian, Li, Xie, Zhan, Ruonan, Mo, Kemin, Zhang, Lijuan, Qian, Yajie, Sun, Yuying, Wang, Aoxue, Zou, Yejun, Chen, Weicai, Li, Yan, Huang, Li, Yang, Yi, Zhao, Yuzheng, Cheng, Xiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413652/
https://www.ncbi.nlm.nih.gov/pubmed/37267363
http://dx.doi.org/10.1126/sciadv.adg4993

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