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Buffering of genetic dominance by allele-specific protein complex assembly

Protein complex assembly often occurs while subunits are being translated, resulting in complexes whose subunits were translated from the same mRNA in an allele-specific manner. It has thus been hypothesized that such cotranslational assembly may counter the assembly-mediated dominant-negative effec...

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Detalles Bibliográficos
Autores principales: Badonyi, Mihaly, Marsh, Joseph A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413657/
https://www.ncbi.nlm.nih.gov/pubmed/37256959
http://dx.doi.org/10.1126/sciadv.adf9845