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Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala
Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it is poorly understood whether contextual representations are imbued with emotional values to support memory selection. Here, we performed activity-dependent...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413664/ https://www.ncbi.nlm.nih.gov/pubmed/37256958 http://dx.doi.org/10.1126/sciadv.adg4881 |
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author | Nguyen, Robin Koukoutselos, Konstantinos Forro, Thomas Ciocchi, Stéphane |
author_facet | Nguyen, Robin Koukoutselos, Konstantinos Forro, Thomas Ciocchi, Stéphane |
author_sort | Nguyen, Robin |
collection | PubMed |
description | Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it is poorly understood whether contextual representations are imbued with emotional values to support memory selection. Here, we performed activity-dependent engram tagging and in vivo single-unit electrophysiological recordings from the ventral hippocampus (vH) while optogenetically manipulating basolateral amygdala (BLA) inputs during the formation of cued fear extinction memory. During fear extinction when CS acquire safety properties, we found that CS-related activity in the vH reactivated during sleep consolidation and was strengthened upon memory retrieval. Moreover, fear extinction memory was facilitated when the extinction context exhibited precise coding of its affective zones. Last, these activity patterns along with the retrieval of the fear extinction memory were dependent on glutamatergic transmission from the BLA during extinction learning. Thus, fear extinction memory relies on the formation of contextual and stimulus safety representations in the vH instructed by the BLA. |
format | Online Article Text |
id | pubmed-10413664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104136642023-08-11 Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala Nguyen, Robin Koukoutselos, Konstantinos Forro, Thomas Ciocchi, Stéphane Sci Adv Neuroscience Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it is poorly understood whether contextual representations are imbued with emotional values to support memory selection. Here, we performed activity-dependent engram tagging and in vivo single-unit electrophysiological recordings from the ventral hippocampus (vH) while optogenetically manipulating basolateral amygdala (BLA) inputs during the formation of cued fear extinction memory. During fear extinction when CS acquire safety properties, we found that CS-related activity in the vH reactivated during sleep consolidation and was strengthened upon memory retrieval. Moreover, fear extinction memory was facilitated when the extinction context exhibited precise coding of its affective zones. Last, these activity patterns along with the retrieval of the fear extinction memory were dependent on glutamatergic transmission from the BLA during extinction learning. Thus, fear extinction memory relies on the formation of contextual and stimulus safety representations in the vH instructed by the BLA. American Association for the Advancement of Science 2023-05-31 /pmc/articles/PMC10413664/ /pubmed/37256958 http://dx.doi.org/10.1126/sciadv.adg4881 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Neuroscience Nguyen, Robin Koukoutselos, Konstantinos Forro, Thomas Ciocchi, Stéphane Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala |
title | Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala |
title_full | Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala |
title_fullStr | Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala |
title_full_unstemmed | Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala |
title_short | Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala |
title_sort | fear extinction relies on ventral hippocampal safety codes shaped by the amygdala |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413664/ https://www.ncbi.nlm.nih.gov/pubmed/37256958 http://dx.doi.org/10.1126/sciadv.adg4881 |
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