Gain-of-function mutations in the catalytic domain of DOT1L promote lung cancer malignant phenotypes via the MAPK/ERK signaling pathway

Lung cancer is a lethal malignancy lacking effective therapies. Emerging evidence suggests that epigenetic enzyme mutations are closely related to the malignant phenotype of lung cancer. Here, we identified a series of gain-of-function mutations in the histone methyltransferase DOT1L. The strongest...

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Detalles Bibliográficos
Autores principales: Zhang, Jiayu, Yang, Ting, Han, Mei, Wang, Xiaoxuan, Yang, Weiming, Guo, Ning, Ren, Yong, Cui, Wei, Li, Shangxiao, Zhao, Yongshan, Zhai, Xin, Jia, Lina, Yang, Jingyu, Wu, Chunfu, Wang, Lihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413674/
https://www.ncbi.nlm.nih.gov/pubmed/37256945
http://dx.doi.org/10.1126/sciadv.adc9273

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