FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks

DNA interstrand crosslinks (ICLs) pose a major obstacle for DNA replication and transcription if left unrepaired. The cellular response to ICLs requires the coordination of various DNA repair mechanisms. Homologous recombination (HR) intermediates generated in response to ICLs, require efficient and...

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Detalles Bibliográficos
Autores principales: Mazouzi, Abdelghani, Moser, Sarah C., Abascal, Federico, van den Broek, Bram, Del Castillo Velasco-Herrera, Martin, van der Heijden, Ingrid, Hekkelman, Maarten, Drenth, Anne Paulien, van der Burg, Eline, Kroese, Lona J., Jalink, Kees, Adams, David J., Jonkers, Jos, Brummelkamp, Thijn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413679/
https://www.ncbi.nlm.nih.gov/pubmed/37256941
http://dx.doi.org/10.1126/sciadv.adf4409

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