Cargando…

Local delivery of hrBMP4 as an anticancer therapy in patients with recurrent glioblastoma: a first-in-human phase 1 dose escalation trial

BACKGROUND: This Phase 1 study evaluates the intra- and peritumoral administration by convection enhanced delivery (CED) of human recombinant Bone Morphogenetic Protein 4 (hrBMP4) – an inhibitory regulator of cancer stem cells (CSCs) – in recurrent glioblastoma. METHODS: In a 3 + 3 dose escalation d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bos, Eelke M., Binda, Elena, Verploegh, Iris S.C., Wembacher, Eva, Hoefnagel, Daphna, Balvers, Rutger K., Korporaal, Anne L., Conidi, Andrea, Warnert, Esther A. H., Trivieri, Nadia, Visioli, Alberto, Zaccarini, Paola, Caiola, Laura, van Wijck, Rogier, van der Spek, Peter, Huylebroeck, Danny, Leenstra, Sieger, Lamfers, Martine L.M., Ram, Zvi, Westphal, Manfred, Noske, David, Legnani, Federico, DiMeco, Francesco, Vescovi, Angelo Luigi, Dirven, Clemens M.F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Correspondence
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413694/ https://www.ncbi.nlm.nih.gov/pubmed/37563568 http://dx.doi.org/10.1186/s12943-023-01835-6

Ejemplares similares

Comparative single-cell RNA-sequencing profiling of BMP4-treated primary glioma cultures reveals therapeutic markers
por: Verploegh, Iris S C, et al.
Publicado: (2022)

ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells
por: Balvers, Rutger K, et al.
Publicado: (2015)

Growth factor independence underpins a paroxysmal, aggressive Wnt5a(High)/EphA2(Low) phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy
por: Trivieri, Nadia, et al.
Publicado: (2022)

The In Vivo Therapeutic Efficacy of the Oncolytic Adenovirus Delta24-RGD Is Mediated by Tumor-Specific Immunity
por: Kleijn, Anne, et al.
Publicado: (2014)

Advancements, Challenges, and Future Directions in Tackling Glioblastoma Resistance to Small Kinase Inhibitors
por: Fabro, Federica, et al.
Publicado: (2022)

Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
por: Visioli, Alberto, et al.
Publicado: (2023)

Locally-Delivered T-Cell-Derived Cellular Vehicles Efficiently Track and Deliver Adenovirus Delta24-RGD to Infiltrating Glioma
por: Balvers, Rutger K., et al.
Publicado: (2014)

A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells
por: Kleijn, A., et al.
Publicado: (2016)

Drug Repurposing, a Fast-Track Approach to Develop Effective Treatments for Glioblastoma
por: Ntafoulis, Ioannis, et al.
Publicado: (2022)

The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells
por: Berghauser Pont, Lotte M.E., et al.
Publicado: (2015)

The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells
por: Berghauser Pont, Lotte M.E., et al.
Publicado: (2014)

Effects of the IDH1 R132H Mutation on the Energy Metabolism: A Comparison between Tissue and Corresponding Primary Glioma Cell Cultures
por: Dekker, Lennard J. M., et al.
Publicado: (2022)

Novel kinome profiling technology reveals drug treatment is patient and 2D/3D model dependent in glioblastoma
por: Fabro, Federica, et al.
Publicado: (2022)

The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8(+)T Cell Anti-tumor Activity
por: Kleijn, Anne, et al.
Publicado: (2017)

Advanced Ultrasound Imaging in Glioma Surgery: Beyond Gray-Scale B-mode
por: Del Bene, Massimiliano, et al.
Publicado: (2018)

May we deliver neuro-oncology in difficult times (e.g. COVID-19)?
por: Perin, Alessandro, et al.
Publicado: (2020)

Anatomical Differences Determine Distribution of Adenovirus after Convection-Enhanced Delivery to the Rat Brain
por: Idema, Sander, et al.
Publicado: (2011)

Image guidance in skull base tumor resection: A synergistic approach using intraoperative navigated angiosonography for real-time vessel visualization
por: Prada, Francesco, et al.
Publicado: (2016)

Editorial: Intraoperative Ultrasound in Brain Tumor Surgery: State-Of-The-Art and Future Perspectives
por: Del Bene, Massimiliano, et al.
Publicado: (2021)

Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies
por: van Putten, Erik H.P., et al.
Publicado: (2022)

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures
por: Verheul, Cassandra, et al.
Publicado: (2021)

Prevention of Post-Operative Pain after Elective Brain Surgery: A Meta-Analysis of Randomized Controlled Trials
por: Fiore, Giorgio, et al.
Publicado: (2023)

Recent advances in the molecular understanding of glioblastoma
por: Bleeker, Fonnet E., et al.
Publicado: (2012)

Current and Future Novel Treatments for Glioblastoma Multiforme
por: Tyler, Betty, et al.
Publicado: (2014)

Intraoperative B-Mode Ultrasound Guided Surgery and the Extent of Glioblastoma Resection: A Randomized Controlled Trial
por: Incekara, Fatih, et al.
Publicado: (2021)

From Grey Scale B-Mode to Elastosonography: Multimodal Ultrasound Imaging in Meningioma Surgery—Pictorial Essay and Literature Review
por: Prada, Francesco, et al.
Publicado: (2015)

Impact of an external ventricular shunt (EVD) handling protocol on secondary meningitis rates: a historical cohort study with propensity score matching
por: Hoefnagel, Daphna, et al.
Publicado: (2023)

Editorial. Neurosurgery in the storm of COVID-19: suggestions from the Lombardy region, Italy (ex malo bonum)
por: Cenzato, Marco, et al.
Publicado: (2020)

Personalizing Oncolytic Virotherapy for Glioblastoma: In Search of Biomarkers for Response
por: Stavrakaki, Eftychia, et al.
Publicado: (2021)

Intraoperative Cerebral Glioma Characterization with Contrast Enhanced Ultrasound
por: Prada, Francesco, et al.
Publicado: (2014)

Reactivation of COVID-19 in a neurosurgical patient with early neuropsychiatric presentation. Does seroconversion mean immunity?
por: Bonomo, Giulio, et al.
Publicado: (2021)

Contemporary frameless intracranial biopsy techniques: Might variation in safety and efficacy be expected?
por: Verploegh, Iris S. C., et al.
Publicado: (2015)

Extracellular vesicles: The key for precision medicine in glioblastoma
por: Del Bene, Massimiliano, et al.
Publicado: (2021)

The temperature‐size rule in Daphnia magna across different genetic lines and ontogenetic stages: Multiple patterns and mechanisms
por: Hoefnagel, K. Natan, et al.
Publicado: (2018)

Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers
por: Ntafoulis, Ioannis, et al.
Publicado: (2023)

BRAF(V600E) mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies
por: Trivieri, Nadia, et al.
Publicado: (2020)

Tumor-initiating cell frequency is relevant for glioblastoma aggressiveness
por: Richichi, Cristina, et al.
Publicado: (2016)

Does early resection of presumed low-grade glioma improve survival? A clinical perspective
por: Wijnenga, Maarten M. J., et al.
Publicado: (2017)

Ultrasounds induce blood–brain barrier opening across a sonolucent polyolefin plate in an in vitro isolated brain preparation
por: Librizzi, Laura, et al.
Publicado: (2022)

Multiparametric Intraoperative Ultrasound in Oncological Neurosurgery: A Pictorial Essay
por: Prada, Francesco, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i5phtf3aged2pl4bevjd3q0fpk