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Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation
BACKGROUND: The clinical relevance of serum glial fibrillary acidic protein (sGFAP) concentration as a biomarker of MS disability progression independent of acute inflammation has yet to be quantified. OBJECTIVE: To test whether baseline values and longitudinal changes in sGFAP concentration are ass...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413790/ https://www.ncbi.nlm.nih.gov/pubmed/37317870 http://dx.doi.org/10.1177/13524585231176732 |
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author | Jiang, Xiaotong Shen, Changyu Teunissen, Charlotte E Wessels, Mark Zetterberg, Henrik Giovannoni, Gavin Singh, Carol M Caba, Bastien Elliott, Colm Fisher, Elizabeth de Moor, Carl Belachew, Shibeshih Gafson, Arie R |
author_facet | Jiang, Xiaotong Shen, Changyu Teunissen, Charlotte E Wessels, Mark Zetterberg, Henrik Giovannoni, Gavin Singh, Carol M Caba, Bastien Elliott, Colm Fisher, Elizabeth de Moor, Carl Belachew, Shibeshih Gafson, Arie R |
author_sort | Jiang, Xiaotong |
collection | PubMed |
description | BACKGROUND: The clinical relevance of serum glial fibrillary acidic protein (sGFAP) concentration as a biomarker of MS disability progression independent of acute inflammation has yet to be quantified. OBJECTIVE: To test whether baseline values and longitudinal changes in sGFAP concentration are associated with disability progression without detectable relapse of magnetic resonance imaging (MRI) inflammatory activity in participants with secondary-progressive multiple sclerosis (SPMS). METHODS: We retrospectively analyzed longitudinal sGFAP concentration and clinical outcome data from the Phase 3 ASCEND trial of participants with SPMS, with no detectable relapse or MRI signs of inflammatory activity at baseline nor during the study (n = 264). Serum neurofilament (sNfL), sGFAP, T2 lesion volume, Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25FW), 9-Hole Peg Test (9HPT), and composite confirmed disability progression (CDP) were measured. Linear and logistic regressions and generalized estimating equations were used in the prognostic and dynamic analyses. RESULTS: We found a significant cross-sectional association between baseline sGFAP and sNfL concentrations and T2 lesion volume. No or weak correlations between sGFAP concentration and changes in EDSS, T25FW, and 9HPT, or CDP were observed. CONCLUSION: Without inflammatory activity, changes in sGFAP concentration in participants with SPMS were neither associated with current nor predictive of future disability progression. |
format | Online Article Text |
id | pubmed-10413790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-104137902023-08-11 Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation Jiang, Xiaotong Shen, Changyu Teunissen, Charlotte E Wessels, Mark Zetterberg, Henrik Giovannoni, Gavin Singh, Carol M Caba, Bastien Elliott, Colm Fisher, Elizabeth de Moor, Carl Belachew, Shibeshih Gafson, Arie R Mult Scler Original Research Papers BACKGROUND: The clinical relevance of serum glial fibrillary acidic protein (sGFAP) concentration as a biomarker of MS disability progression independent of acute inflammation has yet to be quantified. OBJECTIVE: To test whether baseline values and longitudinal changes in sGFAP concentration are associated with disability progression without detectable relapse of magnetic resonance imaging (MRI) inflammatory activity in participants with secondary-progressive multiple sclerosis (SPMS). METHODS: We retrospectively analyzed longitudinal sGFAP concentration and clinical outcome data from the Phase 3 ASCEND trial of participants with SPMS, with no detectable relapse or MRI signs of inflammatory activity at baseline nor during the study (n = 264). Serum neurofilament (sNfL), sGFAP, T2 lesion volume, Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25FW), 9-Hole Peg Test (9HPT), and composite confirmed disability progression (CDP) were measured. Linear and logistic regressions and generalized estimating equations were used in the prognostic and dynamic analyses. RESULTS: We found a significant cross-sectional association between baseline sGFAP and sNfL concentrations and T2 lesion volume. No or weak correlations between sGFAP concentration and changes in EDSS, T25FW, and 9HPT, or CDP were observed. CONCLUSION: Without inflammatory activity, changes in sGFAP concentration in participants with SPMS were neither associated with current nor predictive of future disability progression. SAGE Publications 2023-06-15 2023-08 /pmc/articles/PMC10413790/ /pubmed/37317870 http://dx.doi.org/10.1177/13524585231176732 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Papers Jiang, Xiaotong Shen, Changyu Teunissen, Charlotte E Wessels, Mark Zetterberg, Henrik Giovannoni, Gavin Singh, Carol M Caba, Bastien Elliott, Colm Fisher, Elizabeth de Moor, Carl Belachew, Shibeshih Gafson, Arie R Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation |
title | Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation |
title_full | Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation |
title_fullStr | Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation |
title_full_unstemmed | Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation |
title_short | Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation |
title_sort | glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation |
topic | Original Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413790/ https://www.ncbi.nlm.nih.gov/pubmed/37317870 http://dx.doi.org/10.1177/13524585231176732 |
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