Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages

Persistent inflammation contributes to various inflammatory conditions. Inflammation-related diseases may be treated by inhibiting pro-inflammatory mediators and cytokines. Curcumin and coumarin derivatives can target signalling pathways and cellular factors to address immune-related and inflammator...

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Detalles Bibliográficos
Autores principales: Ghany, Lina M. A. Abdel, Beshay, Botros Y., Youssef Moustafa, Amal M., Maghrabi, Ali Hassan Ahmed, Ali, Eman Hussain Khalifa, Saleem, Rasha Mohammed, Zaki, Islam, Ryad, Noha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413923/
https://www.ncbi.nlm.nih.gov/pubmed/37558232
http://dx.doi.org/10.1080/14756366.2023.2243551

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