Cargando…

Driver Mutations of Pancreatic Cancer Affect Ca(2+) Signaling and ATP Production

Glandular pancreatic epithelia of the acinar or ductal phenotype may seem terminally differentiated, but they are characterized by remarkable cell plasticity. Stress-induced trans-differentiation of these cells has been implicated in the mechanisms of carcinogenesis. Current consensus links pancreat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stopa, Kinga B, Łoziński, Filip, Kusiak, Agnieszka A, Litewka, Jacek, Krzysztofik, Daria, Mosiołek, Sylwester, Morys, Jan, Ferdek, Paweł E, Jakubowska, Monika A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413928/ https://www.ncbi.nlm.nih.gov/pubmed/37575483 http://dx.doi.org/10.1093/function/zqad035

Ejemplares similares

Pancreatic Cancer and Its Microenvironment—Recent Advances and Current Controversies
por: Stopa, Kinga B., et al.
Publicado: (2020)

Activation of pancreatic stellate cells attenuates intracellular Ca(2+) signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites
por: Kusiak, Agnieszka A., et al.
Publicado: (2022)

Signaling in the Physiology and Pathophysiology of Pancreatic Stellate Cells – a Brief Review of Recent Advances
por: Kusiak, Agnieszka A., et al.
Publicado: (2020)

On BH3 Mimetics and Ca(2+) Signaling
por: Ferdek, Pawel E., et al.
Publicado: (2017)

Biology of pancreatic stellate cells—more than just pancreatic cancer
por: Ferdek, Pawel E., et al.
Publicado: (2017)

Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis
por: Paw, Milena, et al.
Publicado: (2023)

Computer Model of Synapse Loss During an Alzheimer’s Disease-Like Pathology in Hippocampal Subregions DG, CA3 and CA1—The Way to Chaos and Information Transfer
por: Świetlik, Dariusz, et al.
Publicado: (2019)

Computer Modeling of Alzheimer’s Disease—Simulations of Synaptic Plasticity and Memory in the CA3-CA1 Hippocampal Formation Microcircuit
por: Świetlik, Dariusz, et al.
Publicado: (2019)

BH3 mimetic-elicited Ca(2+) signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca(2+)-like peptides
por: Ferdek, Pawel E, et al.
Publicado: (2017)

Effects of Inducing Gamma Oscillations in Hippocampal Subregions DG, CA3, and CA1 on the Potential Alleviation of Alzheimer’s Disease-Related Pathology: Computer Modeling and Simulations
por: Świetlik, Dariusz, et al.
Publicado: (2019)

Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation
por: Jakubowska, Monika A., et al.
Publicado: (2016)

Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium‐driven bile uptake
por: Ferdek, Pawel E., et al.
Publicado: (2016)

ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca(2+)‐signalling dysregulation or toxicity in pancreatic acinar cells
por: Jakubowska, Monika A, et al.
Publicado: (2018)

Inhibitors of Bcl-2 protein family deplete ER Ca(2+) stores in pancreatic acinar cells
por: Gerasimenko, Julia, et al.
Publicado: (2010)

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research
por: Yang, Xinmin, et al.
Publicado: (2020)

Editorial: Spotlight on the Background Actors - Physiology and Pathophysiology of Supporting, Accessory and Less Common Cell Types in the Gastrointestinal Tract
por: Ferdek, Pawel E., et al.
Publicado: (2020)

BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis
por: Vervliet, Tim, et al.
Publicado: (2018)

A microRNA checkpoint for Ca(2+) signaling and overload in acute pancreatitis
por: Du, Wenya, et al.
Publicado: (2022)

Usefulness of non-contrast-enhanced magnetic resonance imaging prior to venous interventions
por: Kusiak, Agnieszka, et al.
Publicado: (2019)

Brain-Derived Neurotrophic Factor (BDNF) as an Indicator for Effects of Cognitive Behavioral Therapy (CBT): A Systematic Review
por: Mosiołek, Anna, et al.
Publicado: (2022)

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
por: Wójcik-Pszczoła, Katarzyna, et al.
Publicado: (2020)

Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells
por: Tarasov, Andrei I., et al.
Publicado: (2012)

The Effects of Treatment in Psychotic Disorders—Changes in BDNF Levels and Clinical Outcomes: Systematic Review
por: Mosiołek, Anna, et al.
Publicado: (2023)

The Mitochondrial Ca(2+) Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells
por: Tarasov, Andrei I., et al.
Publicado: (2012)

Ca(2+)-Dependent and Ca(2+)-Independent ATP Release in Astrocytes
por: Xiong, Yingfei, et al.
Publicado: (2018)

Regulation of ATP production by mitochondrial Ca(2+)
por: Tarasov, Andrei I., et al.
Publicado: (2012)

Performance of IOTA Simple Rules Risks, ADNEX Model, Subjective Assessment Compared to CA125 and HE4 with ROMA Algorithm in Discriminating between Benign, Borderline and Stage I Malignant Adnexal Lesions
por: Czekierdowski, Artur, et al.
Publicado: (2023)

Poor Metabolic Health Increases COVID-19-Related Mortality in the UK Biobank Sample
por: Morys, Filip, et al.
Publicado: (2021)

Cognitive impairment in schizophrenia across age groups: a case–control study
por: Mosiołek, Anna, et al.
Publicado: (2016)

Both RyRs and TPCs are required for NAADP-induced intracellular Ca(2+) release
por: Gerasimenko, Julia V., et al.
Publicado: (2015)

Epithelial Cells of Deep Infiltrating Endometriosis Harbor Mutations in Cancer Driver Genes
por: Koppolu, Agnieszka, et al.
Publicado: (2021)

Electron paramagnetic resonance spectroscopy reveals alterations in the redox state of endogenous copper and iron complexes in photodynamic stress-induced ischemic mouse liver
por: Jakubowska, Monika A., et al.
Publicado: (2020)

Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis via Oxidative Stress and PI3K/Akt Signaling Pathway
por: Yang, Xinmin, et al.
Publicado: (2022)

Structural changes induced in Ca2+-regulated myosin filaments by Ca2+ and ATP
Publicado: (1989)

Effects of Antidepressant Treatment on Neurotrophic Factors (BDNF and IGF-1) in Patients with Major Depressive Disorder (MDD)
por: Mosiołek, Anna, et al.
Publicado: (2021)

Dorsolateral and medial prefrontal cortex mediate the influence of incidental priming on economic decision making in obesity
por: Morys, Filip, et al.
Publicado: (2018)

Brain Responses to High-Calorie Visual Food Cues in Individuals with Normal-Weight or Obesity: An Activation Likelihood Estimation Meta-Analysis
por: Yang, Yingkai, et al.
Publicado: (2021)

ATP consumption in molecular signaling of CA1 Hippocampus neurons
por: Rasumov, Nikon, et al.
Publicado: (2015)

Ca(2+)/H(+) exchange, lumenal Ca(2+) release and Ca(2+)/ATP coupling ratios in the sarcoplasmic reticulum ATPase
por: Inesi, Giuseppe, et al.
Publicado: (2013)

Is obesity related to enhanced neural reactivity to visual food cues? A review and meta-analysis
por: Morys, Filip, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ag4439bm3i7f54mtr92g98en5u