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Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios

BACKGROUND: Cognitive impairment is the main manifestation of diabetes central neuropathy. Currently, there is no effective dementia treatment; early diagnosis and treatment are particularly crucial. Inflammation index fibrinogen-to-albumin ratio (FAR) has been shown to predict complications of type...

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Autores principales: Li, Xinyu, Wu, Qian, Kong, Yanqi, Lu, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414025/
https://www.ncbi.nlm.nih.gov/pubmed/37576498
http://dx.doi.org/10.7717/peerj.15826
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author Li, Xinyu
Wu, Qian
Kong, Yanqi
Lu, Chong
author_facet Li, Xinyu
Wu, Qian
Kong, Yanqi
Lu, Chong
author_sort Li, Xinyu
collection PubMed
description BACKGROUND: Cognitive impairment is the main manifestation of diabetes central neuropathy. Currently, there is no effective dementia treatment; early diagnosis and treatment are particularly crucial. Inflammation index fibrinogen-to-albumin ratio (FAR) has been shown to predict complications of type 2 diabetes (diabetic kidney disease and diabetes-related arteriosclerosis), but its relationship with mild cognitive impairment (MCI) in type 2 diabetes (T2D) is undetermined. In this study, we examined the association between the FAR and mild cognitive impairment in type 2 diabetes. METHODS: This is a retrospective and cross-sectional study. From January 2022 to December 2022, we have retrieved 328 inpatient medical records for T2D patients hospitalized at the First Hospital of Harbin Medical University from the hospital’s electronic system. Subjects’ cognitive function was assessed and grouped by the MoCA scales. Subjects’ demographic and various laboratory indicators were collected. Using Spearman’s bivariate correlation analysis, the FAR and other clinical variables were analyzed for association strength. A multiple linear regression analysis was conducted to determine the independent relationship between FAR and MoCA scores. Multivariate logistic regression was used to analyze the independent relationship between FAR and MCI. The capacity of the FAR to detect MCI was carried using receiver operating characteristic (ROC) analysis. RESULTS: The included participants’ (n = 328; 61.9% male) mean age was 52.62 ± 10.92 years. MoCA scores and MCI prevalence significantly differed (p < 0.05) between the four subgroups of FAR quartiles. The FAR and the MoCA score were significantly negatively correlated in the entire population (p < 0.05). Based on the multiple linear regression analysis, lnFAR and lnMoCA are significantly correlated (β = −0.449, t = −8.21, p < 0.05, R2 = 0.469). In multivariate logistic regression analysis, FAR and MCI were independently correlated after adjusting for covariates (OR 95% CI 34.70 [13.90–86.66]). Finally, the analysis of receptor working characteristics shows that the optimal FAR cut-off value was 0.08 (sensitivity: 95.81%, specificity: 84.47%) for detecting MCI in type 2 diabetes. CONCLUSION: In type 2 diabetes, the FAR was positive associations with MCI and negative associations with MoCA score. The high FAR was associated with an increased risk of MCI. FAR maybe a appropriate indicator of MCI risk for type 2 diabetes.
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spelling pubmed-104140252023-08-11 Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios Li, Xinyu Wu, Qian Kong, Yanqi Lu, Chong PeerJ Cognitive Disorders BACKGROUND: Cognitive impairment is the main manifestation of diabetes central neuropathy. Currently, there is no effective dementia treatment; early diagnosis and treatment are particularly crucial. Inflammation index fibrinogen-to-albumin ratio (FAR) has been shown to predict complications of type 2 diabetes (diabetic kidney disease and diabetes-related arteriosclerosis), but its relationship with mild cognitive impairment (MCI) in type 2 diabetes (T2D) is undetermined. In this study, we examined the association between the FAR and mild cognitive impairment in type 2 diabetes. METHODS: This is a retrospective and cross-sectional study. From January 2022 to December 2022, we have retrieved 328 inpatient medical records for T2D patients hospitalized at the First Hospital of Harbin Medical University from the hospital’s electronic system. Subjects’ cognitive function was assessed and grouped by the MoCA scales. Subjects’ demographic and various laboratory indicators were collected. Using Spearman’s bivariate correlation analysis, the FAR and other clinical variables were analyzed for association strength. A multiple linear regression analysis was conducted to determine the independent relationship between FAR and MoCA scores. Multivariate logistic regression was used to analyze the independent relationship between FAR and MCI. The capacity of the FAR to detect MCI was carried using receiver operating characteristic (ROC) analysis. RESULTS: The included participants’ (n = 328; 61.9% male) mean age was 52.62 ± 10.92 years. MoCA scores and MCI prevalence significantly differed (p < 0.05) between the four subgroups of FAR quartiles. The FAR and the MoCA score were significantly negatively correlated in the entire population (p < 0.05). Based on the multiple linear regression analysis, lnFAR and lnMoCA are significantly correlated (β = −0.449, t = −8.21, p < 0.05, R2 = 0.469). In multivariate logistic regression analysis, FAR and MCI were independently correlated after adjusting for covariates (OR 95% CI 34.70 [13.90–86.66]). Finally, the analysis of receptor working characteristics shows that the optimal FAR cut-off value was 0.08 (sensitivity: 95.81%, specificity: 84.47%) for detecting MCI in type 2 diabetes. CONCLUSION: In type 2 diabetes, the FAR was positive associations with MCI and negative associations with MoCA score. The high FAR was associated with an increased risk of MCI. FAR maybe a appropriate indicator of MCI risk for type 2 diabetes. PeerJ Inc. 2023-08-07 /pmc/articles/PMC10414025/ /pubmed/37576498 http://dx.doi.org/10.7717/peerj.15826 Text en © 2023 Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Cognitive Disorders
Li, Xinyu
Wu, Qian
Kong, Yanqi
Lu, Chong
Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios
title Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios
title_full Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios
title_fullStr Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios
title_full_unstemmed Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios
title_short Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios
title_sort mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios
topic Cognitive Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414025/
https://www.ncbi.nlm.nih.gov/pubmed/37576498
http://dx.doi.org/10.7717/peerj.15826
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