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Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review

Nitrofurantoin (NF), a wide-spectrum antibiotic accessible since 1953, is utilized widely to treat urinary tract infections as it usually stays active against drug-resistant uropathogen. The use of Nitrofurantoin has increased exponentially since new guidelines have repositioned it as first-line the...

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Autores principales: Mahdizade Ari, Marzie, Dashtbin, Shirin, Ghasemi, Fatemeh, Shahroodian, Soheila, kiani, Parisa, Bafandeh, Elnaz, Darbandi, Talieh, Ghanavati, Roya, Darbandi, Atieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414118/
https://www.ncbi.nlm.nih.gov/pubmed/37577377
http://dx.doi.org/10.3389/fcimb.2023.1148603
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author Mahdizade Ari, Marzie
Dashtbin, Shirin
Ghasemi, Fatemeh
Shahroodian, Soheila
kiani, Parisa
Bafandeh, Elnaz
Darbandi, Talieh
Ghanavati, Roya
Darbandi, Atieh
author_facet Mahdizade Ari, Marzie
Dashtbin, Shirin
Ghasemi, Fatemeh
Shahroodian, Soheila
kiani, Parisa
Bafandeh, Elnaz
Darbandi, Talieh
Ghanavati, Roya
Darbandi, Atieh
author_sort Mahdizade Ari, Marzie
collection PubMed
description Nitrofurantoin (NF), a wide-spectrum antibiotic accessible since 1953, is utilized widely to treat urinary tract infections as it usually stays active against drug-resistant uropathogen. The use of Nitrofurantoin has increased exponentially since new guidelines have repositioned it as first-line therapy for uncomplicated lower urinary tract infection (UTI). To, although fluoroquinolones are usually used to re-evaluate the first- and second-line therapies for treating uncomplicated UTI, their level of utilization is thought to be inappropriately excessive and will eventually have a detrimental impact; thus, we hypothesize that NF might be the best choice for this condition, because of its low frequency of utilization and its high susceptibility in common UTI pathogens. It can be concluded from this review that NF can be considered as the most effective drug in the treatment of acute urinary infection, but due to the long-term side effects of this drug, especially in elderly patients, it is essential to introduce some criteria for prescribing NF in cases of chronic UTI.
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spelling pubmed-104141182023-08-11 Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review Mahdizade Ari, Marzie Dashtbin, Shirin Ghasemi, Fatemeh Shahroodian, Soheila kiani, Parisa Bafandeh, Elnaz Darbandi, Talieh Ghanavati, Roya Darbandi, Atieh Front Cell Infect Microbiol Cellular and Infection Microbiology Nitrofurantoin (NF), a wide-spectrum antibiotic accessible since 1953, is utilized widely to treat urinary tract infections as it usually stays active against drug-resistant uropathogen. The use of Nitrofurantoin has increased exponentially since new guidelines have repositioned it as first-line therapy for uncomplicated lower urinary tract infection (UTI). To, although fluoroquinolones are usually used to re-evaluate the first- and second-line therapies for treating uncomplicated UTI, their level of utilization is thought to be inappropriately excessive and will eventually have a detrimental impact; thus, we hypothesize that NF might be the best choice for this condition, because of its low frequency of utilization and its high susceptibility in common UTI pathogens. It can be concluded from this review that NF can be considered as the most effective drug in the treatment of acute urinary infection, but due to the long-term side effects of this drug, especially in elderly patients, it is essential to introduce some criteria for prescribing NF in cases of chronic UTI. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10414118/ /pubmed/37577377 http://dx.doi.org/10.3389/fcimb.2023.1148603 Text en Copyright © 2023 Mahdizade Ari, Dashtbin, Ghasemi, Shahroodian, kiani, Bafandeh, Darbandi, Ghanavati and Darbandi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Mahdizade Ari, Marzie
Dashtbin, Shirin
Ghasemi, Fatemeh
Shahroodian, Soheila
kiani, Parisa
Bafandeh, Elnaz
Darbandi, Talieh
Ghanavati, Roya
Darbandi, Atieh
Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review
title Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review
title_full Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review
title_fullStr Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review
title_full_unstemmed Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review
title_short Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review
title_sort nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414118/
https://www.ncbi.nlm.nih.gov/pubmed/37577377
http://dx.doi.org/10.3389/fcimb.2023.1148603
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