Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation

BACKGROUND: Despite its potential utility in delivering direct tumor killing and in situ whole-cell tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical response, limiting its clinical utility. The mechanism(s) driving cryoablation-induced local antitumor immunit...

Descripción completa

Detalles Bibliográficos
Autores principales: Alshebremi, Mohammad, Tomchuck, Suzanne L, Myers, Jay T, Kingsley, Daniel T, Eid, Saada, Abiff, Muta, Bonner, Melissa, Saab, Shahrazad T, Choi, Sung Hee, Huang, Alex Yee-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414127/
https://www.ncbi.nlm.nih.gov/pubmed/37553183
http://dx.doi.org/10.1136/jitc-2022-006608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414127/
https://www.ncbi.nlm.nih.gov/pubmed/37553183
http://dx.doi.org/10.1136/jitc-2022-006608

Ejemplares similares