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Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation

BACKGROUND: Despite its potential utility in delivering direct tumor killing and in situ whole-cell tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical response, limiting its clinical utility. The mechanism(s) driving cryoablation-induced local antitumor immunit...

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Detalles Bibliográficos
Autores principales:	Alshebremi, Mohammad, Tomchuck, Suzanne L, Myers, Jay T, Kingsley, Daniel T, Eid, Saada, Abiff, Muta, Bonner, Melissa, Saab, Shahrazad T, Choi, Sung Hee, Huang, Alex Yee-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414127/ https://www.ncbi.nlm.nih.gov/pubmed/37553183 http://dx.doi.org/10.1136/jitc-2022-006608

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