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Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia
In Cambodia, traditional medicine was commonly described as being used by pregnant women at two time points: one month before birth and during early postpartum. The present study aims to describe traditional medicine consumption during postpartum phase for women enrolled in the TA PROHM study and to...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414559/ https://www.ncbi.nlm.nih.gov/pubmed/37561767 http://dx.doi.org/10.1371/journal.pone.0288389 |
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author | Moeung, Sotheara Chassagne, François Goyet, Sophie Nhoeung, Sovann Sun, Lynecta Yang, Dorina Vilhem, Steve Dim, Bunnet Ly, Socheat Sov, Linda Sreng, Vouchleang Chorn, Sokda Chhun, Samsorphea Borand, Laurence Kim, Sothea Segeral, Olivier |
author_facet | Moeung, Sotheara Chassagne, François Goyet, Sophie Nhoeung, Sovann Sun, Lynecta Yang, Dorina Vilhem, Steve Dim, Bunnet Ly, Socheat Sov, Linda Sreng, Vouchleang Chorn, Sokda Chhun, Samsorphea Borand, Laurence Kim, Sothea Segeral, Olivier |
author_sort | Moeung, Sotheara |
collection | PubMed |
description | In Cambodia, traditional medicine was commonly described as being used by pregnant women at two time points: one month before birth and during early postpartum. The present study aims to describe traditional medicine consumption during postpartum phase for women enrolled in the TA PROHM study and to investigate the possible association between traditional medicine consumption and acute liver toxicity. An ethnobotanical survey was conducted in 2 groups of HBV-infected pregnant women (with and without postpartum hepatocellular injury) enrolled in the study. Hepatocellular injury was defined by having Alanine Aminotransferase (ALT) > 2.5 times the Upper Limit of Normal (ULN = 40 U/L) at the 6(th) week postpartum visit. Interviews were done using a standardized questionnaire. Plant samples were collected and later identified by two traditional healers. Chi-square test was used to find the association between hepatocellular injury and traditional medicine consumption or a specific plant species. In total, 75 women were enrolled and 52 (69.3%) used at least one traditional remedy composed of 123 different plants and 12 alcoholic macerations of porcupine stomach. Orally consuming at least one remedy with alcohol was significantly associated with hepatocellular injury (33% vs 13%, p = 0.034). Among the 123 plants species identified, four were found to be associated with hepatocellular injury, namely Amphineurion marginatum (Roxb.) D.J.Middleton [Apocynaceae] (p = 0.022), Selaginella tamariscina (P.Beauv.) Spring [Selaginellaceae] (p = 0.048), Mitragyna speciosa Korth. [Rubiaceae] (p = 0.099) and Tetracera indica (Christm. & Panz.) Merr. [Dilleniaceae] (p = 0.079). Consumption of traditional medicine in postpartum is a common practice for women enrolled in the TA PROHM study. Alcohol-based remedies may exacerbate the risk of acute hepatocellular injury in HBV-infected women already exposed to immune restoration. The complex mixtures of herbs need to be further evaluated by in vitro and in vivo studies. |
format | Online Article Text |
id | pubmed-10414559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104145592023-08-11 Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia Moeung, Sotheara Chassagne, François Goyet, Sophie Nhoeung, Sovann Sun, Lynecta Yang, Dorina Vilhem, Steve Dim, Bunnet Ly, Socheat Sov, Linda Sreng, Vouchleang Chorn, Sokda Chhun, Samsorphea Borand, Laurence Kim, Sothea Segeral, Olivier PLoS One Research Article In Cambodia, traditional medicine was commonly described as being used by pregnant women at two time points: one month before birth and during early postpartum. The present study aims to describe traditional medicine consumption during postpartum phase for women enrolled in the TA PROHM study and to investigate the possible association between traditional medicine consumption and acute liver toxicity. An ethnobotanical survey was conducted in 2 groups of HBV-infected pregnant women (with and without postpartum hepatocellular injury) enrolled in the study. Hepatocellular injury was defined by having Alanine Aminotransferase (ALT) > 2.5 times the Upper Limit of Normal (ULN = 40 U/L) at the 6(th) week postpartum visit. Interviews were done using a standardized questionnaire. Plant samples were collected and later identified by two traditional healers. Chi-square test was used to find the association between hepatocellular injury and traditional medicine consumption or a specific plant species. In total, 75 women were enrolled and 52 (69.3%) used at least one traditional remedy composed of 123 different plants and 12 alcoholic macerations of porcupine stomach. Orally consuming at least one remedy with alcohol was significantly associated with hepatocellular injury (33% vs 13%, p = 0.034). Among the 123 plants species identified, four were found to be associated with hepatocellular injury, namely Amphineurion marginatum (Roxb.) D.J.Middleton [Apocynaceae] (p = 0.022), Selaginella tamariscina (P.Beauv.) Spring [Selaginellaceae] (p = 0.048), Mitragyna speciosa Korth. [Rubiaceae] (p = 0.099) and Tetracera indica (Christm. & Panz.) Merr. [Dilleniaceae] (p = 0.079). Consumption of traditional medicine in postpartum is a common practice for women enrolled in the TA PROHM study. Alcohol-based remedies may exacerbate the risk of acute hepatocellular injury in HBV-infected women already exposed to immune restoration. The complex mixtures of herbs need to be further evaluated by in vitro and in vivo studies. Public Library of Science 2023-08-10 /pmc/articles/PMC10414559/ /pubmed/37561767 http://dx.doi.org/10.1371/journal.pone.0288389 Text en © 2023 Moeung et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Moeung, Sotheara Chassagne, François Goyet, Sophie Nhoeung, Sovann Sun, Lynecta Yang, Dorina Vilhem, Steve Dim, Bunnet Ly, Socheat Sov, Linda Sreng, Vouchleang Chorn, Sokda Chhun, Samsorphea Borand, Laurence Kim, Sothea Segeral, Olivier Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia |
title | Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia |
title_full | Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia |
title_fullStr | Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia |
title_full_unstemmed | Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia |
title_short | Traditional medicine consumption in postpartum for HBV-infected women enrolled in the ANRS 12345 TA PROHM study in Cambodia |
title_sort | traditional medicine consumption in postpartum for hbv-infected women enrolled in the anrs 12345 ta prohm study in cambodia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414559/ https://www.ncbi.nlm.nih.gov/pubmed/37561767 http://dx.doi.org/10.1371/journal.pone.0288389 |
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