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Time separating spatial memories does not influence their integration in humans
Humans can navigate through similar environments—like grocery stores—by integrating across their memories to extract commonalities or by differentiating between each to find idiosyncratic locations. Here, we investigate one factor that might impact whether two related spatial memories are integrated...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414573/ https://www.ncbi.nlm.nih.gov/pubmed/37561677 http://dx.doi.org/10.1371/journal.pone.0289649 |
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author | Fang, Xiaoping Alsbury-Nealy, Benjamin Wang, Ying Frankland, Paul W. Josselyn, Sheena A. Schlichting, Margaret L. Duncan, Katherine D. |
author_facet | Fang, Xiaoping Alsbury-Nealy, Benjamin Wang, Ying Frankland, Paul W. Josselyn, Sheena A. Schlichting, Margaret L. Duncan, Katherine D. |
author_sort | Fang, Xiaoping |
collection | PubMed |
description | Humans can navigate through similar environments—like grocery stores—by integrating across their memories to extract commonalities or by differentiating between each to find idiosyncratic locations. Here, we investigate one factor that might impact whether two related spatial memories are integrated or differentiated: Namely, the temporal delay between experiences. Rodents have been shown to integrate memories more often when they are formed within 6 hours of each other. To test if this effect influences how humans spontaneously integrate spatial memories, we had 131 participants search for rewards in two similar virtual environments. We separated these learning experiences by either 30 minutes, 3 hours, or 27 hours. Memory integration was assessed three days later. Participants were able to integrate and simultaneously differentiate related memories across experiences. However, neither memory integration nor differentiation was modulated by temporal delay, in contrast to previous work. We further showed that both the levels of initial memory reactivation during the second experience and memory generalization to novel environments were comparable across conditions. Moreover, perseveration toward the initial reward locations during the second experience was related positively to integration and negatively to differentiation—but again, these associations did not vary by delay. Our findings identify important boundary conditions on the translation of rodent memory mechanisms to humans, motivating more research to characterize how even fundamental memory mechanisms are conserved and diverge across species. |
format | Online Article Text |
id | pubmed-10414573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104145732023-08-11 Time separating spatial memories does not influence their integration in humans Fang, Xiaoping Alsbury-Nealy, Benjamin Wang, Ying Frankland, Paul W. Josselyn, Sheena A. Schlichting, Margaret L. Duncan, Katherine D. PLoS One Research Article Humans can navigate through similar environments—like grocery stores—by integrating across their memories to extract commonalities or by differentiating between each to find idiosyncratic locations. Here, we investigate one factor that might impact whether two related spatial memories are integrated or differentiated: Namely, the temporal delay between experiences. Rodents have been shown to integrate memories more often when they are formed within 6 hours of each other. To test if this effect influences how humans spontaneously integrate spatial memories, we had 131 participants search for rewards in two similar virtual environments. We separated these learning experiences by either 30 minutes, 3 hours, or 27 hours. Memory integration was assessed three days later. Participants were able to integrate and simultaneously differentiate related memories across experiences. However, neither memory integration nor differentiation was modulated by temporal delay, in contrast to previous work. We further showed that both the levels of initial memory reactivation during the second experience and memory generalization to novel environments were comparable across conditions. Moreover, perseveration toward the initial reward locations during the second experience was related positively to integration and negatively to differentiation—but again, these associations did not vary by delay. Our findings identify important boundary conditions on the translation of rodent memory mechanisms to humans, motivating more research to characterize how even fundamental memory mechanisms are conserved and diverge across species. Public Library of Science 2023-08-10 /pmc/articles/PMC10414573/ /pubmed/37561677 http://dx.doi.org/10.1371/journal.pone.0289649 Text en © 2023 Fang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fang, Xiaoping Alsbury-Nealy, Benjamin Wang, Ying Frankland, Paul W. Josselyn, Sheena A. Schlichting, Margaret L. Duncan, Katherine D. Time separating spatial memories does not influence their integration in humans |
title | Time separating spatial memories does not influence their integration in humans |
title_full | Time separating spatial memories does not influence their integration in humans |
title_fullStr | Time separating spatial memories does not influence their integration in humans |
title_full_unstemmed | Time separating spatial memories does not influence their integration in humans |
title_short | Time separating spatial memories does not influence their integration in humans |
title_sort | time separating spatial memories does not influence their integration in humans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414573/ https://www.ncbi.nlm.nih.gov/pubmed/37561677 http://dx.doi.org/10.1371/journal.pone.0289649 |
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