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Time separating spatial memories does not influence their integration in humans

Humans can navigate through similar environments—like grocery stores—by integrating across their memories to extract commonalities or by differentiating between each to find idiosyncratic locations. Here, we investigate one factor that might impact whether two related spatial memories are integrated...

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Autores principales: Fang, Xiaoping, Alsbury-Nealy, Benjamin, Wang, Ying, Frankland, Paul W., Josselyn, Sheena A., Schlichting, Margaret L., Duncan, Katherine D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414573/
https://www.ncbi.nlm.nih.gov/pubmed/37561677
http://dx.doi.org/10.1371/journal.pone.0289649
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author Fang, Xiaoping
Alsbury-Nealy, Benjamin
Wang, Ying
Frankland, Paul W.
Josselyn, Sheena A.
Schlichting, Margaret L.
Duncan, Katherine D.
author_facet Fang, Xiaoping
Alsbury-Nealy, Benjamin
Wang, Ying
Frankland, Paul W.
Josselyn, Sheena A.
Schlichting, Margaret L.
Duncan, Katherine D.
author_sort Fang, Xiaoping
collection PubMed
description Humans can navigate through similar environments—like grocery stores—by integrating across their memories to extract commonalities or by differentiating between each to find idiosyncratic locations. Here, we investigate one factor that might impact whether two related spatial memories are integrated or differentiated: Namely, the temporal delay between experiences. Rodents have been shown to integrate memories more often when they are formed within 6 hours of each other. To test if this effect influences how humans spontaneously integrate spatial memories, we had 131 participants search for rewards in two similar virtual environments. We separated these learning experiences by either 30 minutes, 3 hours, or 27 hours. Memory integration was assessed three days later. Participants were able to integrate and simultaneously differentiate related memories across experiences. However, neither memory integration nor differentiation was modulated by temporal delay, in contrast to previous work. We further showed that both the levels of initial memory reactivation during the second experience and memory generalization to novel environments were comparable across conditions. Moreover, perseveration toward the initial reward locations during the second experience was related positively to integration and negatively to differentiation—but again, these associations did not vary by delay. Our findings identify important boundary conditions on the translation of rodent memory mechanisms to humans, motivating more research to characterize how even fundamental memory mechanisms are conserved and diverge across species.
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spelling pubmed-104145732023-08-11 Time separating spatial memories does not influence their integration in humans Fang, Xiaoping Alsbury-Nealy, Benjamin Wang, Ying Frankland, Paul W. Josselyn, Sheena A. Schlichting, Margaret L. Duncan, Katherine D. PLoS One Research Article Humans can navigate through similar environments—like grocery stores—by integrating across their memories to extract commonalities or by differentiating between each to find idiosyncratic locations. Here, we investigate one factor that might impact whether two related spatial memories are integrated or differentiated: Namely, the temporal delay between experiences. Rodents have been shown to integrate memories more often when they are formed within 6 hours of each other. To test if this effect influences how humans spontaneously integrate spatial memories, we had 131 participants search for rewards in two similar virtual environments. We separated these learning experiences by either 30 minutes, 3 hours, or 27 hours. Memory integration was assessed three days later. Participants were able to integrate and simultaneously differentiate related memories across experiences. However, neither memory integration nor differentiation was modulated by temporal delay, in contrast to previous work. We further showed that both the levels of initial memory reactivation during the second experience and memory generalization to novel environments were comparable across conditions. Moreover, perseveration toward the initial reward locations during the second experience was related positively to integration and negatively to differentiation—but again, these associations did not vary by delay. Our findings identify important boundary conditions on the translation of rodent memory mechanisms to humans, motivating more research to characterize how even fundamental memory mechanisms are conserved and diverge across species. Public Library of Science 2023-08-10 /pmc/articles/PMC10414573/ /pubmed/37561677 http://dx.doi.org/10.1371/journal.pone.0289649 Text en © 2023 Fang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fang, Xiaoping
Alsbury-Nealy, Benjamin
Wang, Ying
Frankland, Paul W.
Josselyn, Sheena A.
Schlichting, Margaret L.
Duncan, Katherine D.
Time separating spatial memories does not influence their integration in humans
title Time separating spatial memories does not influence their integration in humans
title_full Time separating spatial memories does not influence their integration in humans
title_fullStr Time separating spatial memories does not influence their integration in humans
title_full_unstemmed Time separating spatial memories does not influence their integration in humans
title_short Time separating spatial memories does not influence their integration in humans
title_sort time separating spatial memories does not influence their integration in humans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414573/
https://www.ncbi.nlm.nih.gov/pubmed/37561677
http://dx.doi.org/10.1371/journal.pone.0289649
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