Functional Engagement of the PD-1/PD-L1 Complex But Not PD-L1 Expression Is Highly Predictive of Patient Response to Immunotherapy in Non–Small-Cell Lung Cancer

In many cancers, the expression of immunomodulatory ligands leads to immunoevasion, as exemplified by the interaction of PD-L1 with PD-1 on tumor-infiltrating lymphocytes. Profound advances in cancer treatments have come with the advent of immunotherapies directed at blocking these immuno-suppressiv...

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Detalles Bibliográficos
Autores principales: Sánchez-Magraner, Lissete, Gumuzio, Juan, Miles, James, Quimi, Nicole, Martínez del Prado, Purificación, Abad-Villar, María Teresa, Pikabea, Fernando, Ortega, Laura, Etxezarraga, Carmen, Martín-Algarra, Salvador, Lozano, María D., Saiz-Camin, Mónica, Egurrola-Izquierdo, Mikel, Barredo-Santamaría, Inmaculada, Saiz-López, Alberto, Gomez-Mediavilla, Jenifer, Segues-Merino, Nerea, Juaristi-Abaunz, María Aranzazu, Urruticoechea, Ander, Geraedts, Erica J., van Elst, Kim, Claessens, Niels J.M., Italiano, Antoine, Applebee, Christopher J., del Castillo, Sandra, Evans, Charles, Aguirre, Fernando, Parker, Peter J., Calleja, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2023
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414696/
https://www.ncbi.nlm.nih.gov/pubmed/36821809
http://dx.doi.org/10.1200/JCO.22.01748

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