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Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer
To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two validation cohorts across two biospecimen types (formalin-fixed paraffin-embedded and...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414761/ https://www.ncbi.nlm.nih.gov/pubmed/37541199 http://dx.doi.org/10.1016/j.cell.2023.07.004 |
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| author | Chowdhury, Shrabanti Kennedy, Jacob J. Ivey, Richard G. Murillo, Oscar D. Hosseini, Noshad Song, Xiaoyu Petralia, Francesca Calinawan, Anna Savage, Sara R. Berry, Anna B. Reva, Boris Ozbek, Umut Krek, Azra Ma, Weiping da Veiga Leprevost, Felipe Ji, Jiayi Yoo, Seungyeul Lin, Chenwei Voytovich, Uliana J. Huang, Yajue Lee, Sun-Hee Bergan, Lindsay Lorentzen, Travis D. Mesri, Mehdi Rodriguez, Henry Hoofnagle, Andrew N. Herbert, Zachary T. Nesvizhskii, Alexey I. Zhang, Bing Whiteaker, Jeffrey R. Fenyo, David McKerrow, Wilson Wang, Joshua Schürer, Stephan C. Stathias, Vasileios Chen, X. Steven Barcellos-Hoff, Mary Helen Starr, Timothy K. Winterhoff, Boris J. Nelson, Andrew C. Mok, Samuel C. Kaufmann, Scott H. Drescher, Charles Cieslik, Marcin Wang, Pei Birrer, Michael J. Paulovich, Amanda G. |
| author_facet | Chowdhury, Shrabanti Kennedy, Jacob J. Ivey, Richard G. Murillo, Oscar D. Hosseini, Noshad Song, Xiaoyu Petralia, Francesca Calinawan, Anna Savage, Sara R. Berry, Anna B. Reva, Boris Ozbek, Umut Krek, Azra Ma, Weiping da Veiga Leprevost, Felipe Ji, Jiayi Yoo, Seungyeul Lin, Chenwei Voytovich, Uliana J. Huang, Yajue Lee, Sun-Hee Bergan, Lindsay Lorentzen, Travis D. Mesri, Mehdi Rodriguez, Henry Hoofnagle, Andrew N. Herbert, Zachary T. Nesvizhskii, Alexey I. Zhang, Bing Whiteaker, Jeffrey R. Fenyo, David McKerrow, Wilson Wang, Joshua Schürer, Stephan C. Stathias, Vasileios Chen, X. Steven Barcellos-Hoff, Mary Helen Starr, Timothy K. Winterhoff, Boris J. Nelson, Andrew C. Mok, Samuel C. Kaufmann, Scott H. Drescher, Charles Cieslik, Marcin Wang, Pei Birrer, Michael J. Paulovich, Amanda G. |
| author_sort | Chowdhury, Shrabanti |
| collection | PubMed |
| description | To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two validation cohorts across two biospecimen types (formalin-fixed paraffin-embedded and frozen). We identified a 64-protein signature that predicts with high specificity a subset of HGSOCs refractory to initial platinum-based therapy and is validated in two independent patient cohorts. We detected significant association between lack of Ch17 loss of heterozygosity (LOH) and chemo-refractoriness. Based on pathway protein expression, we identified 5 clusters of HGSOC, which validated across two independent patient cohorts and patient-derived xenograft (PDX) models. These clusters may represent different mechanisms of refractoriness and implicate putative therapeutic vulnerabilities. |
| format | Online Article Text |
| id | pubmed-10414761 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104147612023-08-10 Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer Chowdhury, Shrabanti Kennedy, Jacob J. Ivey, Richard G. Murillo, Oscar D. Hosseini, Noshad Song, Xiaoyu Petralia, Francesca Calinawan, Anna Savage, Sara R. Berry, Anna B. Reva, Boris Ozbek, Umut Krek, Azra Ma, Weiping da Veiga Leprevost, Felipe Ji, Jiayi Yoo, Seungyeul Lin, Chenwei Voytovich, Uliana J. Huang, Yajue Lee, Sun-Hee Bergan, Lindsay Lorentzen, Travis D. Mesri, Mehdi Rodriguez, Henry Hoofnagle, Andrew N. Herbert, Zachary T. Nesvizhskii, Alexey I. Zhang, Bing Whiteaker, Jeffrey R. Fenyo, David McKerrow, Wilson Wang, Joshua Schürer, Stephan C. Stathias, Vasileios Chen, X. Steven Barcellos-Hoff, Mary Helen Starr, Timothy K. Winterhoff, Boris J. Nelson, Andrew C. Mok, Samuel C. Kaufmann, Scott H. Drescher, Charles Cieslik, Marcin Wang, Pei Birrer, Michael J. Paulovich, Amanda G. Cell Article To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two validation cohorts across two biospecimen types (formalin-fixed paraffin-embedded and frozen). We identified a 64-protein signature that predicts with high specificity a subset of HGSOCs refractory to initial platinum-based therapy and is validated in two independent patient cohorts. We detected significant association between lack of Ch17 loss of heterozygosity (LOH) and chemo-refractoriness. Based on pathway protein expression, we identified 5 clusters of HGSOC, which validated across two independent patient cohorts and patient-derived xenograft (PDX) models. These clusters may represent different mechanisms of refractoriness and implicate putative therapeutic vulnerabilities. 2023-08-03 /pmc/articles/PMC10414761/ /pubmed/37541199 http://dx.doi.org/10.1016/j.cell.2023.07.004 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
| spellingShingle | Article Chowdhury, Shrabanti Kennedy, Jacob J. Ivey, Richard G. Murillo, Oscar D. Hosseini, Noshad Song, Xiaoyu Petralia, Francesca Calinawan, Anna Savage, Sara R. Berry, Anna B. Reva, Boris Ozbek, Umut Krek, Azra Ma, Weiping da Veiga Leprevost, Felipe Ji, Jiayi Yoo, Seungyeul Lin, Chenwei Voytovich, Uliana J. Huang, Yajue Lee, Sun-Hee Bergan, Lindsay Lorentzen, Travis D. Mesri, Mehdi Rodriguez, Henry Hoofnagle, Andrew N. Herbert, Zachary T. Nesvizhskii, Alexey I. Zhang, Bing Whiteaker, Jeffrey R. Fenyo, David McKerrow, Wilson Wang, Joshua Schürer, Stephan C. Stathias, Vasileios Chen, X. Steven Barcellos-Hoff, Mary Helen Starr, Timothy K. Winterhoff, Boris J. Nelson, Andrew C. Mok, Samuel C. Kaufmann, Scott H. Drescher, Charles Cieslik, Marcin Wang, Pei Birrer, Michael J. Paulovich, Amanda G. Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer |
| title | Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer |
| title_full | Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer |
| title_fullStr | Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer |
| title_full_unstemmed | Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer |
| title_short | Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer |
| title_sort | proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414761/ https://www.ncbi.nlm.nih.gov/pubmed/37541199 http://dx.doi.org/10.1016/j.cell.2023.07.004 |
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