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Emerging roles of PHLPP phosphatases in lung cancer

Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis. With the continuous expansion of PHLPPs research, imbalanced-PHLPPs were mainly...

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Autores principales: Xia, Xinhang, Pi, Wenhu, Chen, Meng, Wang, Wei, Cai, Danyang, Wang, Xuequan, Lan, Yanli, Yang, Haihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414793/
https://www.ncbi.nlm.nih.gov/pubmed/37576883
http://dx.doi.org/10.3389/fonc.2023.1216131
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author Xia, Xinhang
Pi, Wenhu
Chen, Meng
Wang, Wei
Cai, Danyang
Wang, Xuequan
Lan, Yanli
Yang, Haihua
author_facet Xia, Xinhang
Pi, Wenhu
Chen, Meng
Wang, Wei
Cai, Danyang
Wang, Xuequan
Lan, Yanli
Yang, Haihua
author_sort Xia, Xinhang
collection PubMed
description Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis. With the continuous expansion of PHLPPs research, imbalanced-PHLPPs were mainly found as a tumor suppressor gene of a variety of solid tumors. In this review, we simply described the history and structures of PHLPPs and summarized the recent achievements in emerging roles of PHLPPs in lung cancer by 1) the signaling pathways affected by PHLPPs including Phosphoinositide 3-kinase (PI3K)/AKT, RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and Protein kinase C (PKC) signaling cascades. 2) function of PHLPPs regulatory factor USP46 and miR-190/miR-215, 3) the potential roles of PHLPPs in disease prognosis, Epidermal growth factor receptors (EGFR)- tyrosine kinase inhibitor (TKI) resistance and DNA damage, 4) and the possible function of PHLPPs in radiotherapy, ferroptosis and inflammation response. Therefore, PHLPPs can be considered as either biomarker or prognostic marker for lung cancer treatment.
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spelling pubmed-104147932023-08-11 Emerging roles of PHLPP phosphatases in lung cancer Xia, Xinhang Pi, Wenhu Chen, Meng Wang, Wei Cai, Danyang Wang, Xuequan Lan, Yanli Yang, Haihua Front Oncol Oncology Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis. With the continuous expansion of PHLPPs research, imbalanced-PHLPPs were mainly found as a tumor suppressor gene of a variety of solid tumors. In this review, we simply described the history and structures of PHLPPs and summarized the recent achievements in emerging roles of PHLPPs in lung cancer by 1) the signaling pathways affected by PHLPPs including Phosphoinositide 3-kinase (PI3K)/AKT, RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and Protein kinase C (PKC) signaling cascades. 2) function of PHLPPs regulatory factor USP46 and miR-190/miR-215, 3) the potential roles of PHLPPs in disease prognosis, Epidermal growth factor receptors (EGFR)- tyrosine kinase inhibitor (TKI) resistance and DNA damage, 4) and the possible function of PHLPPs in radiotherapy, ferroptosis and inflammation response. Therefore, PHLPPs can be considered as either biomarker or prognostic marker for lung cancer treatment. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10414793/ /pubmed/37576883 http://dx.doi.org/10.3389/fonc.2023.1216131 Text en Copyright © 2023 Xia, Pi, Chen, Wang, Cai, Wang, Lan and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xia, Xinhang
Pi, Wenhu
Chen, Meng
Wang, Wei
Cai, Danyang
Wang, Xuequan
Lan, Yanli
Yang, Haihua
Emerging roles of PHLPP phosphatases in lung cancer
title Emerging roles of PHLPP phosphatases in lung cancer
title_full Emerging roles of PHLPP phosphatases in lung cancer
title_fullStr Emerging roles of PHLPP phosphatases in lung cancer
title_full_unstemmed Emerging roles of PHLPP phosphatases in lung cancer
title_short Emerging roles of PHLPP phosphatases in lung cancer
title_sort emerging roles of phlpp phosphatases in lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414793/
https://www.ncbi.nlm.nih.gov/pubmed/37576883
http://dx.doi.org/10.3389/fonc.2023.1216131
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