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Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation

The 3243A > G in mtDNA is a representative mutation in mitochondrial diseases. Mitochondrial protein synthesis is impaired due to decoding disorder caused by severe reduction of 5-taurinomethyluridine (τm(5)U) modification of the mutant mt-tRNA(Leu(UUR)) bearing 3243A > G mutation. The 3243A &...

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Detalles Bibliográficos
Autores principales:	Ueda, Saori, Yagi, Mikako, Tomoda, Ena, Matsumoto, Shinya, Ueyanagi, Yasushi, Do, Yura, Setoyama, Daiki, Matsushima, Yuichi, Nagao, Asuteka, Suzuki, Tsutomu, Ide, Tomomi, Mori, Yusuke, Oyama, Noriko, Kang, Dongchon, Uchiumi, Takeshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415116/ https://www.ncbi.nlm.nih.gov/pubmed/37439353 http://dx.doi.org/10.1093/nar/gkad591

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