ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development

ZMYM2 is a transcriptional repressor whose role in development is largely unexplored. We found that Zmym2(−/−) mice show embryonic lethality by E10.5. Molecular characterization of Zmym2(−/−) embryos revealed two distinct defects. First, they fail to undergo DNA methylation and silencing of germline...

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Detalles Bibliográficos
Autores principales: Graham-Paquin, Adda-Lee, Saini, Deepak, Sirois, Jacinthe, Hossain, Ishtiaque, Katz, Megan S, Zhuang, Qinwei Kim-Wee, Kwon, Sin Young, Yamanaka, Yojiro, Bourque, Guillaume, Bouchard, Maxime, Pastor, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415128/
https://www.ncbi.nlm.nih.gov/pubmed/37395395
http://dx.doi.org/10.1093/nar/gkad540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415128/
https://www.ncbi.nlm.nih.gov/pubmed/37395395
http://dx.doi.org/10.1093/nar/gkad540

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