A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium

The selenocysteine (Sec) tRNA (tRNA([Ser]Sec)) governs Sec insertion into selenoproteins by the recoding of a UGA codon, typically used as a stop codon. A homozygous point mutation (C65G) in the human tRNA([Ser]Sec) acceptor arm has been reported by two independent groups and was associated with sym...

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Detalles Bibliográficos
Autores principales: Vindry, Caroline, Guillin, Olivia, Wolff, Philippe, Marie, Paul, Mortreux, Franck, Mangeot, Philippe E, Ohlmann, Théophile, Chavatte, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415148/
https://www.ncbi.nlm.nih.gov/pubmed/37254812
http://dx.doi.org/10.1093/nar/gkad482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415148/
https://www.ncbi.nlm.nih.gov/pubmed/37254812
http://dx.doi.org/10.1093/nar/gkad482

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