Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases

Mutations in mitochondrial (mt-)tRNAs frequently cause mitochondrial dysfunction. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and myoclonus epilepsy associated with ragged red fibers (MERRF) are major clinical subgroups of mitochondrial diseases caused...

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Detalles Bibliográficos
Autores principales: Tomoda, Ena, Nagao, Asuteka, Shirai, Yuki, Asano, Kana, Suzuki, Takeo, Battersby, Brendan J, Suzuki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415153/
https://www.ncbi.nlm.nih.gov/pubmed/36928678
http://dx.doi.org/10.1093/nar/gkad139

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