RNase H1 facilitates recombinase recruitment by degrading DNA–RNA hybrids during meiosis

DNA–RNA hybrids play various roles in many physiological progresses, but how this chromatin structure is dynamically regulated during spermatogenesis remains largely unknown. Here, we show that germ cell-specific knockout of Rnaseh1, a specialized enzyme that degrades the RNA within DNA–RNA hybrids,...

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Detalles Bibliográficos
Autores principales: Liu, Chao, Wang, Liying, Li, Yanan, Guo, Mengmeng, Hu, Jun, Wang, Teng, Li, Mengjing, Yang, Zhuo, Lin, Ruoyao, Xu, Wei, Chen, Yinghong, Luo, Mengcheng, Gao, Fei, Chen, Jia-Yu, Sun, Qianwen, Liu, Hongbin, Sun, Bo, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415156/
https://www.ncbi.nlm.nih.gov/pubmed/37378420
http://dx.doi.org/10.1093/nar/gkad524

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