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Unveiling the Role of Hormonal Imbalance in Breast Cancer Development: A Comprehensive Review

Breast cancer is a complex and multifactorial disease with a significant global impact. Hormonal imbalance has emerged as a crucial factor in breast cancer development, highlighting the importance of understanding the intricate interplay between hormones and breast tissue. This comprehensive review...

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Autores principales: Satpathi, Shweta, Gaurkar, Sagar S, Potdukhe, Ashwini, Wanjari, Mayur B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415229/
https://www.ncbi.nlm.nih.gov/pubmed/37575755
http://dx.doi.org/10.7759/cureus.41737
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author Satpathi, Shweta
Gaurkar, Sagar S
Potdukhe, Ashwini
Wanjari, Mayur B
author_facet Satpathi, Shweta
Gaurkar, Sagar S
Potdukhe, Ashwini
Wanjari, Mayur B
author_sort Satpathi, Shweta
collection PubMed
description Breast cancer is a complex and multifactorial disease with a significant global impact. Hormonal imbalance has emerged as a crucial factor in breast cancer development, highlighting the importance of understanding the intricate interplay between hormones and breast tissue. This comprehensive review aims to unveil the role of hormonal imbalance in breast cancer by exploring the involvement of key hormones, including estrogen and progesterone, and their receptors in tumor development. The review delves into how hormonal imbalance impacts breast tissue, emphasizing the significance of hormone receptor status in guiding treatment decisions. Furthermore, the review investigates the influence of other hormones, such as insulin and growth factors, and their cross-talk with hormone pathways in breast cancer progression. The implications of hormonal imbalance assessment in breast cancer risk assessment and the importance of hormone testing in diagnosis and treatment decisions are also discussed. Moreover, the review provides an overview of the various hormonal therapies used in breast cancer treatment, their benefits, limitations, and ongoing research efforts to optimize their efficacy and overcome resistance. Future directions in hormonal therapy research, including developing novel therapies and personalized medicine approaches, are explored. This review underscores the need for a comprehensive understanding of hormonal imbalance in breast cancer to enhance prevention, diagnosis, and treatment strategies, ultimately improving outcomes for individuals affected by this disease.
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spelling pubmed-104152292023-08-12 Unveiling the Role of Hormonal Imbalance in Breast Cancer Development: A Comprehensive Review Satpathi, Shweta Gaurkar, Sagar S Potdukhe, Ashwini Wanjari, Mayur B Cureus Medical Education Breast cancer is a complex and multifactorial disease with a significant global impact. Hormonal imbalance has emerged as a crucial factor in breast cancer development, highlighting the importance of understanding the intricate interplay between hormones and breast tissue. This comprehensive review aims to unveil the role of hormonal imbalance in breast cancer by exploring the involvement of key hormones, including estrogen and progesterone, and their receptors in tumor development. The review delves into how hormonal imbalance impacts breast tissue, emphasizing the significance of hormone receptor status in guiding treatment decisions. Furthermore, the review investigates the influence of other hormones, such as insulin and growth factors, and their cross-talk with hormone pathways in breast cancer progression. The implications of hormonal imbalance assessment in breast cancer risk assessment and the importance of hormone testing in diagnosis and treatment decisions are also discussed. Moreover, the review provides an overview of the various hormonal therapies used in breast cancer treatment, their benefits, limitations, and ongoing research efforts to optimize their efficacy and overcome resistance. Future directions in hormonal therapy research, including developing novel therapies and personalized medicine approaches, are explored. This review underscores the need for a comprehensive understanding of hormonal imbalance in breast cancer to enhance prevention, diagnosis, and treatment strategies, ultimately improving outcomes for individuals affected by this disease. Cureus 2023-07-11 /pmc/articles/PMC10415229/ /pubmed/37575755 http://dx.doi.org/10.7759/cureus.41737 Text en Copyright © 2023, Satpathi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Medical Education
Satpathi, Shweta
Gaurkar, Sagar S
Potdukhe, Ashwini
Wanjari, Mayur B
Unveiling the Role of Hormonal Imbalance in Breast Cancer Development: A Comprehensive Review
title Unveiling the Role of Hormonal Imbalance in Breast Cancer Development: A Comprehensive Review
title_full Unveiling the Role of Hormonal Imbalance in Breast Cancer Development: A Comprehensive Review
title_fullStr Unveiling the Role of Hormonal Imbalance in Breast Cancer Development: A Comprehensive Review
title_full_unstemmed Unveiling the Role of Hormonal Imbalance in Breast Cancer Development: A Comprehensive Review
title_short Unveiling the Role of Hormonal Imbalance in Breast Cancer Development: A Comprehensive Review
title_sort unveiling the role of hormonal imbalance in breast cancer development: a comprehensive review
topic Medical Education
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415229/
https://www.ncbi.nlm.nih.gov/pubmed/37575755
http://dx.doi.org/10.7759/cureus.41737
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