Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via germinal center reaction

Emerging SARS-CoV-2 Omicron variants are highly contagious with enhanced immune escape mechanisms against the initially approved COVID-19 vaccines. Therefore, we require stable alternative-platform vaccines that confer protection against newer variants of SARS-CoV-2. We designed an Omicron B.1.1.529...

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Detalles Bibliográficos
Autores principales: Hayashi, Hiroki, Sun, Jiao, Yanagida, Yuka, Otera, Takako, Tai, Jiayu A., Nishikawa, Tomoyuki, Yamashita, Kunihiko, Sakaguchi, Naoki, Yoshida, Shota, Baba, Satoshi, Chang, Chin Yang, Shimamura, Munehisa, Okamoto, Sachiko, Amaishi, Yasunori, Chono, Hideto, Mineno, Junichi, Rakugi, Hiromi, Morishita, Ryuichi, Nakagami, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415318/
https://www.ncbi.nlm.nih.gov/pubmed/37563266
http://dx.doi.org/10.1038/s41598-023-40172-y

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