Cargando…
Serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in Malaysian Borneo
Malaysia has reported no indigenous cases of P. falciparum and P. vivax for over 3 years. When transmission reaches such low levels, it is important to understand the individuals and locations where exposure risks are high, as they may be at greater risk in the case of a resurgence of transmission....
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415323/ https://www.ncbi.nlm.nih.gov/pubmed/37563178 http://dx.doi.org/10.1038/s41598-023-39670-w |
_version_ | 1785087511190568960 |
---|---|
author | Byrne, Isabel William, Timothy Chua, Tock H. Patterson, Catriona Hall, Tom Tan, Mark Chitnis, Chetan Adams, John Singh, Susheel K. Grignard, Lynn Tetteh, Kevin K. A. Fornace, Kimberly M. Drakeley, Chris J. |
author_facet | Byrne, Isabel William, Timothy Chua, Tock H. Patterson, Catriona Hall, Tom Tan, Mark Chitnis, Chetan Adams, John Singh, Susheel K. Grignard, Lynn Tetteh, Kevin K. A. Fornace, Kimberly M. Drakeley, Chris J. |
author_sort | Byrne, Isabel |
collection | PubMed |
description | Malaysia has reported no indigenous cases of P. falciparum and P. vivax for over 3 years. When transmission reaches such low levels, it is important to understand the individuals and locations where exposure risks are high, as they may be at greater risk in the case of a resurgence of transmission. Serology is a useful tool in low transmission settings, providing insight into exposure over longer durations than PCR or RDT. We ran blood samples from a 2015 population-based survey in northern Sabah, Malaysian Borneo on a multiplex bead assay. Using supervised machine learning methods, we characterised recent and historic exposure to Plasmodium falciparum and P. vivax and found recent exposure to P. falciparum to be very low, with exposure to both species increasing with age. We performed a risk-factor assessment on environmental, behavioural, demographic and household factors, and identified forest activity and longer travel times to healthcare as common risk-factors for exposure to P. falciparum and P. vivax. In addition, we used remote-sensing derived data and geostatistical models to assess environmental and spatial associations with exposure. We created predictive maps of exposure to recent P. falciparum in the study area and showed 3 clear foci of exposure. This study provides useful insight into the environmental, spatial and demographic risk factors for P. falciparum and P. vivax at a period of low transmission in Malaysian Borneo. The findings would be valuable in the case of resurgence of human malarias in the region. |
format | Online Article Text |
id | pubmed-10415323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104153232023-08-12 Serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in Malaysian Borneo Byrne, Isabel William, Timothy Chua, Tock H. Patterson, Catriona Hall, Tom Tan, Mark Chitnis, Chetan Adams, John Singh, Susheel K. Grignard, Lynn Tetteh, Kevin K. A. Fornace, Kimberly M. Drakeley, Chris J. Sci Rep Article Malaysia has reported no indigenous cases of P. falciparum and P. vivax for over 3 years. When transmission reaches such low levels, it is important to understand the individuals and locations where exposure risks are high, as they may be at greater risk in the case of a resurgence of transmission. Serology is a useful tool in low transmission settings, providing insight into exposure over longer durations than PCR or RDT. We ran blood samples from a 2015 population-based survey in northern Sabah, Malaysian Borneo on a multiplex bead assay. Using supervised machine learning methods, we characterised recent and historic exposure to Plasmodium falciparum and P. vivax and found recent exposure to P. falciparum to be very low, with exposure to both species increasing with age. We performed a risk-factor assessment on environmental, behavioural, demographic and household factors, and identified forest activity and longer travel times to healthcare as common risk-factors for exposure to P. falciparum and P. vivax. In addition, we used remote-sensing derived data and geostatistical models to assess environmental and spatial associations with exposure. We created predictive maps of exposure to recent P. falciparum in the study area and showed 3 clear foci of exposure. This study provides useful insight into the environmental, spatial and demographic risk factors for P. falciparum and P. vivax at a period of low transmission in Malaysian Borneo. The findings would be valuable in the case of resurgence of human malarias in the region. Nature Publishing Group UK 2023-08-10 /pmc/articles/PMC10415323/ /pubmed/37563178 http://dx.doi.org/10.1038/s41598-023-39670-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Byrne, Isabel William, Timothy Chua, Tock H. Patterson, Catriona Hall, Tom Tan, Mark Chitnis, Chetan Adams, John Singh, Susheel K. Grignard, Lynn Tetteh, Kevin K. A. Fornace, Kimberly M. Drakeley, Chris J. Serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in Malaysian Borneo |
title | Serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in Malaysian Borneo |
title_full | Serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in Malaysian Borneo |
title_fullStr | Serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in Malaysian Borneo |
title_full_unstemmed | Serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in Malaysian Borneo |
title_short | Serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in Malaysian Borneo |
title_sort | serological evaluation of risk factors for exposure to malaria in a pre-elimination setting in malaysian borneo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415323/ https://www.ncbi.nlm.nih.gov/pubmed/37563178 http://dx.doi.org/10.1038/s41598-023-39670-w |
work_keys_str_mv | AT byrneisabel serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT williamtimothy serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT chuatockh serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT pattersoncatriona serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT halltom serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT tanmark serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT chitnischetan serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT adamsjohn serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT singhsusheelk serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT grignardlynn serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT tettehkevinka serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT fornacekimberlym serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo AT drakeleychrisj serologicalevaluationofriskfactorsforexposuretomalariainapreeliminationsettinginmalaysianborneo |